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本文引用的文献

1
Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion.通过实时震颤诱导转化对组织和体液中朊病毒感染性进行定量评估。
J Gen Virol. 2015 Jan;96(Pt 1):210-219. doi: 10.1099/vir.0.069906-0. Epub 2014 Oct 10.
2
Preclinical detection of variant CJD and BSE prions in blood.血液中变异型克雅氏病和牛海绵状脑病朊病毒的临床前检测。
PLoS Pathog. 2014 Jun 12;10(6):e1004202. doi: 10.1371/journal.ppat.1004202. eCollection 2014 Jun.
3
In vitro detection of prionemia in TSE-infected cervids and hamsters.在 TSE 感染的鹿和仓鼠中检测朊病毒血症的体外检测。
PLoS One. 2013 Nov 1;8(11):e80203. doi: 10.1371/journal.pone.0080203. eCollection 2013.
4
Rapid antemortem detection of CWD prions in deer saliva.快速检测鹿唾液中的 CWD 朊病毒。
PLoS One. 2013 Sep 11;8(9):e74377. doi: 10.1371/journal.pone.0074377. eCollection 2013.
5
Mother to offspring transmission of chronic wasting disease in reeves' muntjac deer.麋鹿慢性消瘦病在母代到子代之间的传播。
PLoS One. 2013 Aug 14;8(8):e71844. doi: 10.1371/journal.pone.0071844. eCollection 2013.
6
Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay.现在，使用实时 QUIC 检测法可以早期检测遗传型人类朊病毒病中的异常朊病毒蛋白。
PLoS One. 2013;8(1):e54915. doi: 10.1371/journal.pone.0054915. Epub 2013 Jan 25.
7
Aerosol transmission of chronic wasting disease in white-tailed deer.白尾鹿慢性消耗病的气溶胶传播。
J Virol. 2013 Feb;87(3):1890-2. doi: 10.1128/JVI.02852-12. Epub 2012 Nov 21.
8
Rapid transepithelial transport of prions following inhalation.吸入后朊病毒快速经上皮转运。
J Virol. 2012 Dec;86(23):12731-40. doi: 10.1128/JVI.01930-12. Epub 2012 Sep 12.
9
Highly efficient prion transmission by blood transfusion.高效输血传播朊病毒。
PLoS Pathog. 2012;8(6):e1002782. doi: 10.1371/journal.ppat.1002782. Epub 2012 Jun 21.
10
Detection of prion protein particles in blood plasma of scrapie infected sheep.检测朊病毒感染羊的血浆中的朊病毒颗粒。
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仓鼠和鹿经口、鼻或血液接种后血液中朊病毒的即时和持续检测

Immediate and Ongoing Detection of Prions in the Blood of Hamsters and Deer following Oral, Nasal, or Blood Inoculations.

作者信息

Elder Alan M, Henderson Davin M, Nalls Amy V, Hoover Edward A, Kincaid Anthony E, Bartz Jason C, Mathiason Candace K

出版信息

J Virol. 2015 Jul;89(14):7421-4. doi: 10.1128/JVI.00760-15.

DOI:10.1128/JVI.00760-15
PMID:25926635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4473550/
Abstract

Infectious prions traverse epithelial barriers to gain access to the circulatory system, yet the temporal parameters of transepithelial transport and persistence in the blood over time remain unknown. We used whole-blood real-time quaking-induced conversion (wbRT-QuIC) to analyze whole blood collected from transmissible spongiform encephalopathy (TSE)-inoculated deer and hamsters throughout the incubation period for the presence of common prion protein-conversion competent amyloid (PrPCCCA). We observed PrPC-CCA in the blood of TSE-inoculated hosts throughout the disease course from minutes postexposure to terminal disease.

摘要

传染性朊病毒穿过上皮屏障进入循环系统，但跨上皮运输的时间参数以及其在血液中的长期存在情况仍不清楚。我们使用全血实时颤抖诱导转化（wbRT-QuIC）技术，分析了在整个潜伏期从感染传染性海绵状脑病（TSE）的鹿和仓鼠采集的全血，以检测常见朊病毒蛋白转化活性淀粉样蛋白（PrPCCCA）的存在。我们观察到，在TSE感染宿主的血液中，从暴露后几分钟到疾病末期的整个病程中都存在PrPC-CCA。