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IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.

作者信息

Nabekura Tsukasa, Girard Jean-Philippe, Lanier Lewis L

机构信息

Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143; Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8577, Japan; and.

Centre National de la Recherche Scientifique and Université de Toulouse, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse, France.

出版信息

J Immunol. 2015 Jun 15;194(12):5948-52. doi: 10.4049/jimmunol.1500424. Epub 2015 Apr 29.

DOI:10.4049/jimmunol.1500424
PMID:25926677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4458425/
Abstract

NK cells provide important host defense against viruses and can differentiate into self-renewing memory NK cells after infection, alloantigen stimulation, and cytokine stimulation. In this study, we investigated the role of the IL-33 receptor ST2 in the differentiation of NK cells during mouse CMV (MCMV) infection. Although ST2-deficient (Il1rl1 (-/-)) Ly49H(+) NK cells develop normally and differentiate into memory cells after MCMV infection, naive and memory Il1rl1 (-/-) Ly49H(+) NK cells exhibited profound defects in MCMV-specific expansion, resulting in impaired protection against MCMV challenge. Additionally, IL-33 enhanced m157 Ag-specific proliferation of Ly49H(+) NK cells in vitro. Thus, an IL-33/ST2 signaling axis in NK cells contributes to host defense against MCMV.

摘要

相似文献

[1]
IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.

J Immunol. 2015-6-15

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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[5]
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[6]
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[7]
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[8]
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[9]
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本文引用的文献

[1]
Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion.

J Immunol. 2015-2-15

[2]
Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation.

J Exp Med. 2014-11-17

[3]
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.

Curr Opin Immunol. 2014-9-29

[4]
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Immunity. 2014-1-16

[5]
The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.

J Immunol. 2013-6-3

[6]
Natural killer cells: walking three paths down memory lane.

Trends Immunol. 2013-3-14

[7]
Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen.

J Immunol. 2012-10-17

[8]
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.

J Immunol. 2012-5-25

[9]
Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells.

Front Immunol. 2011-9-12

[10]
Proinflammatory cytokine signaling required for the generation of natural killer cell memory.

J Exp Med. 2012-4-9

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