Durila Miroslav, Lukáš Pavel, Bronský Jiří, Cvachovec Karel
Department of Anaesthesiology and Intensive Care Medicine, Second Faculty of Medicine, Charles University in Prague, University Hospital Motol, V Úvalu 84, 150 06, Prague, 5, Czech Republic.
Department of Paediatrics, Charles University, Second Faculty of Medicine, Prague, Czech Republic.
BMC Anesthesiol. 2015 Apr 15;15:50. doi: 10.1186/s12871-015-0033-9.
The correct methodology of thrombelastography might be influenced by elapsing time. In our study we investigated kaolin activated citrated samples together with non-activated citrated samples in relation to the elapsed times of 0, 15 and 30 minutes to compare both methods and to find out if there is an impact of time on results of thrombelastography.
Blood samples obtained from 10 healthy volunteers were analyzed after 0, 15 and 30 minutes from sampling with kaolin activation and without activation. Then the results were analysed and compared between the non-activated and the kaolin-activated method.
All blood samples became more hypercoagulable with the time elapsing, both in non-activated and kaolin-activated samples and differences between both groups were found statistically and clinically significant after only 0 minutes.
The non-activated citrated method seems to be reliable and suitable for thrombelastography in non-emergency cases (planned surgical procedures) when we have time to wait 15-30 minutes to get results. In urgent situations a rapid thrombelastography test should be preferred. Although the kaolin-activated method can also be used, results must be interpreted with caution.
血栓弹力图的正确方法可能会受到时间流逝的影响。在我们的研究中，我们研究了高岭土激活的枸橼酸盐样本以及未激活的枸橼酸盐样本，涉及0、15和30分钟的时间流逝情况，以比较两种方法，并确定时间是否对血栓弹力图结果有影响。
从10名健康志愿者采集的血样在采样后0、15和30分钟分别进行无激活和高岭土激活分析。然后对未激活和高岭土激活方法的结果进行分析和比较。
随着时间的推移，所有血样的血液凝固性都变得更高，未激活和高岭土激活的样本均如此，且仅在0分钟后两组之间的差异在统计学和临床上就具有显著性。
未激活的枸橼酸盐方法似乎可靠，适用于非紧急情况（计划性手术）下的血栓弹力图检查，此时我们有时间等待15 - 30分钟以获得结果。在紧急情况下，应优先选择快速血栓弹力图检测。虽然高岭土激活方法也可使用，但结果的解释必须谨慎。
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