McIntyre I M, Judd F K, Burrows G D, Norman T R
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.
Int Clin Psychopharmacol. 1989 Jan;4(1):1-6. doi: 10.1097/00004850-198901000-00001.
Platelet serotonin uptake and platelet serotonin concentrations were measured in 17 patients (5 males, 12 females) with panic attacks and 15 controls (8 males, 7 females). Higher Vmax values were found in the patient group compared with controls (65 +/- 7 vs. 47 +/- 3 pmol/10(8) platelets/min; p less than 0.05) while the affinity constant Km was not significantly different (0.6 +/- 0.1 vs. 0.5 +/- 0.1 microM). Platelet serotonin concentrations were not significantly different between the two groups (38 +/- 4 vs. 41 +/- 4 ng/10(8) platelets). These results confirm our earlier finding of increased serotonin uptake in patients with panic attacks and suggest that platelet serotonin levels are normal.
对17名恐慌症患者（5名男性，12名女性）和15名对照者（8名男性，7名女性）测量了血小板5-羟色胺摄取量和血小板5-羟色胺浓度。与对照组相比，患者组的Vmax值更高（65±7对47±3 pmol/10⁸血小板/分钟；p<0.05），而亲和常数Km无显著差异（0.6±0.1对0.5±0.1 microM）。两组之间的血小板5-羟色胺浓度无显著差异（38±4对41±4 ng/10⁸血小板）。这些结果证实了我们早期关于恐慌症患者5-羟色胺摄取增加的发现，并表明血小板5-羟色胺水平正常。
