Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
J Am Chem Soc. 2015 May 13;137(18):5907-10. doi: 10.1021/jacs.5b03531. Epub 2015 May 4.
Muironolide A is a fascinating tetrachlorinated marine polyketide isolated from the sponge of Phorbas sp. Only 90 μg had been isolated, and the structure was established by nanoscale NMR techniques. Herein we report the total synthesis of the substance with the assigned structure of muironolide A, propose a revised structure based on NMR data, and complete the enantioselective total synthesis of muironolide A.
Muironolide A 是一种从海绵 Phorbas sp. 中分离出的迷人的四氯化海洋聚酮。仅分离出 90 μg，其结构通过纳米级 NMR 技术确定。在此，我们报告了该物质的全合成，其结构与 muironolide A 的指定结构一致，基于 NMR 数据提出了一个修订的结构，并完成了 muironolide A 的对映选择性全合成。
