Mayer Kerstin, Wyckoff Sarah Nicole, Fallgatter Andreas J, Ehlis Ann-Christine, Strehl Ute
Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Silcherstrasse 5, 72076, Tübingen, Germany.
Sense Labs, Mesa, AZ, 1918 N. Higley Rd, 85205, Mesa, AZ, USA.
Trials. 2015 Apr 18;16:174. doi: 10.1186/s13063-015-0683-4.
Neurofeedback has been applied effectively in various areas, especially in the treatment of children with attention-deficit/hyperactivity disorder (ADHD). This study protocol is designed to investigate the effect of slow cortical potential (SCP) feedback and a new form of neurofeedback using near-infrared spectroscopy (NIRS) on symptomatology and neurophysiological parameters in an adult ADHD population. A comparison of SCP and NIRS feedback therapy methods has not been previously conducted and may yield valuable findings about alternative treatments for adult ADHD.
METHODS/DESIGN: The outcome of both neurofeedback techniques will be assessed over 30 treatment sessions and after a 6-month follow-up period, and then will be compared to a nonspecific biofeedback treatment. Furthermore, to investigate if treatment effects in this proof-of-principle study can be predicted by specific neurophysiological baseline parameters, regression models will be applied. Finally, a comparison with healthy controls will be conducted to evaluate deviant pretraining neurophysiological parameters, stability of assessment measures, and treatment outcome.
To date, an investigation and comparison of SCP and NIRS feedback training to an active control has not been conducted; therefore, we hope to gain valuable insights in effects and differences of these types of treatment for ADHD in adults.
This study is registered with the German Registry of Clinical Trials: DRKS00006767 , date of registration: 8 October 2014.
神经反馈已在多个领域得到有效应用，尤其是在治疗注意力缺陷多动障碍（ADHD）儿童方面。本研究方案旨在调查慢皮层电位（SCP）反馈和一种使用近红外光谱（NIRS）的新型神经反馈对成人ADHD患者症状学和神经生理学参数的影响。此前尚未对SCP和NIRS反馈治疗方法进行比较，这可能会为成人ADHD的替代治疗带来有价值的发现。
方法/设计：两种神经反馈技术的结果将在30次治疗疗程及6个月随访期后进行评估，然后与非特异性生物反馈治疗进行比较。此外，为了研究在这项原理验证研究中治疗效果是否可以通过特定的神经生理学基线参数进行预测，将应用回归模型。最后，将与健康对照组进行比较，以评估训练前异常的神经生理学参数、评估措施的稳定性和治疗结果。
迄今为止，尚未对SCP和NIRS反馈训练与积极对照进行调查和比较；因此，我们希望能对这些类型的成人ADHD治疗的效果和差异获得有价值的见解。
本研究已在德国临床试验注册中心注册：DRKS00006767，注册日期：2014年10月8日。
