[俄罗斯分离的布尼亚姆韦拉病毒群（布尼亚病毒科，正布尼亚病毒属）中的巴泰病毒（BATV）和新型阿纳德尔病毒（ANADV）的全基因组分析]

[Complete genome analysis of the Batai virus (BATV) and the new Anadyr virus (ANADV) of the Bunyamwera group (Bunyaviridae, Orthobunyavirus) isolated in Russia].

作者信息

Shchetinin A M, Lvov D K, Alkhovsky S V, Shchelkanov M Yu, Aristova V A, Morozova T N, Gitelman A K, Deryabin P G, Botikov A G

出版信息

Vopr Virusol. 2014;59(6):16-22.

PMID:25929031

Abstract

Almost complete nucleotide sequences for the S, M, and L segments were obtained for three strains of the Batai virus (Bunyamwera serogroup, genus Orthobunyavirus, Bunyaviridae family). Based on the results of the phylogenetic analysis conducted forthe three genomic segments LEIV Ast507 and LEIV-Ast528 strains were grouped with other European BATV isolates and were found to be almost identical to the strain 42 isolated from Volgograd Region, Russia, 2003. Surprisingly, LEIV-13395 strain isolated from the Aedes sp. mosquitos in Magadan Oblast, 1987, turned out to be a novel genotype inside Bunyamwera serogroup. The highest nucleotide identity levels of LEIV-13395 genomicsegments (86.9%, 80.8%, 79.7% for S, M and L segments respectively) were observed with corresponding segments of the Batai virus.

摘要

获得了巴泰病毒（布尼亚病毒科正布尼亚病毒属布尼亚姆韦拉血清群）三个毒株的S、M和L片段几乎完整的核苷酸序列。基于对这三个基因组片段进行的系统发育分析结果，LEIV Ast507和LEIV-Ast528毒株与其他欧洲巴泰病毒分离株归为一组，并被发现与2003年从俄罗斯伏尔加格勒地区分离出的42号毒株几乎相同。令人惊讶的是，1987年从马加丹州伊蚊中分离出的LEIV-13395毒株竟然是布尼亚姆韦拉血清群内的一个新基因型。LEIV-13395基因组片段与巴泰病毒相应片段的核苷酸同一性水平最高（S、M和L片段分别为86.9%、80.8%、79.7%）。