The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Brain Imaging Behav. 2021 Jun;15(3):1201-1210. doi: 10.1007/s11682-020-00320-8.
Conduct disorder (CD) is a common psychiatric disorder defined by a repetitive and persistent pattern of aggressive and antisocial behaviors. Although numerous task-based and resting-state functional magnetic resonance imaging (rsfMRI) studies have emphasized the disrupted functional connectivity in CD, the CD-related alterations in functional interactions between the bilateral cerebral hemispheres are rarely investigated directly. In this study, a voxel-mirrored homotopic connectivity (VMHC) method based on rsfMRI was employed for the first time to examine the abnormalities of interhemispheric functional connectivity in patients with CD. The VMHC was compared between eighteen pure CD patients and eighteen typically developing (TD) healthy controls. In CD patients, reduced homotopic connectivity was observed relative to TDs in the middle occipital gyrus (MOG), pre- and postcentral gyrus, rolandic operculum and paracentral lobe (PCL) which were the components of visual and motor networks. Furthermore, the VMHC of the MOG and PCL was found to be negatively correlated with clinical scores in the CD group. Moreover, the regions with altered VMHC exhibited a relative good and robust ability to discriminate CD patients from TDs. This study provided a novel angle to identify the important role of interhemispheric coordination in the pathophysiology underlying CD and further indicated that the aberrant homotopic connectivity could be a potential clinical neural marker for CD diagnosis.
注意缺陷多动障碍（ADHD）是一种常见的精神障碍，其特征是存在反复和持续的攻击性行为和反社会行为。尽管许多基于任务和静息状态功能磁共振成像（rsfMRI）的研究强调了 ADHD 患者大脑功能连接的中断，但大脑两半球之间功能相互作用的 ADHD 相关性改变很少直接进行研究。在这项研究中，首次使用基于 rsfMRI 的体素镜像同伦连接（VMHC）方法来研究 ADHD 患者大脑半球间功能连接的异常。将 18 名单纯 ADHD 患者和 18 名典型发育（TD）健康对照者的 VMHC 进行了比较。与 TD 相比，ADHD 患者大脑中后回（MOG）、中央前回和后回、岛盖部和旁中央叶（PCL）等视觉和运动网络的同伦连接减少。此外，MOG 和 PCL 的 VMHC 与 ADHD 组的临床评分呈负相关。此外，VMHC 改变的区域具有区分 ADHD 患者和 TD 的良好和稳健的能力。这项研究提供了一个新的角度，以确定大脑两半球协调在 ADHD 病理生理学中的重要作用，并进一步表明，异常的同伦连接可能是 ADHD 诊断的潜在临床神经标志物。
