Mir-196a-2基因C>T多态性作为结直肠癌的一个易感因素。
Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
作者信息
Shi Liang, Zhang Chongyang, Zhao Dongqiang, Liu Kexia, Li Tiejun, Tian Hui
机构信息
The First Department of General Surgery, Cangzhou Central Hospital of Hebei Province Xinhua West Road No. 16, Xinhua District, Cangzhou 061001, Hebei Province, China.
Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine in Hebei Hebei Province, China.
出版信息
Int J Clin Exp Med. 2015 Feb 15;8(2):2600-6. eCollection 2015.
OBJECTIVE
This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC).
METHODS
In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources.
RESULTS
We found no overall association between the mir-196a-2 C>T polymorphism and CRC risk. But a significant association was found in the stratified analysis according to ethnicity among Asians (ORCC vs. TT = 1.22, 95% CI = 1.02-1.45, P heterogeneity = 0.718; ORCC vs. TC + TT = 1.22, 95% CI = 1.04-1.44, P heterogeneity = 0.590; ORallele C vs. allele T = 1.10, 95% CI = 1.01-1.20, P heterogeneity = 0.726) rather than Caucasians.
CONCLUSIONS
Our results suggested that there was no overall risk of CRC in relation to the mir-196a-2 C>T polymorphism. However, this polymorphism was associated with an increased risk in Asian populations.
目的
本研究旨在更深入了解mir-196a-2 C>T多态性对结直肠癌（CRC）易感性的影响。
方法
在对6篇共包含1754例癌症病例和2430例对照的文献进行的荟萃分析中，我们总结了所研究的mir-196a-2 C>T多态性与CRC风险之间关联的数据，并按种族和对照来源进行了亚组分析。
结果
我们发现mir-196a-2 C>T多态性与CRC风险之间无总体关联。但在按种族进行的分层分析中，亚洲人存在显著关联（CC与TT相比的比值比=1.22，95%置信区间=1.02-1.45，异质性P值=0.718；CC与TC+TT相比的比值比=1.22，95%置信区间=1.04-1.44，异质性P值=0.590；等位基因C与等位基因T相比的比值比=1.10，95%置信区间=1.01-1.20，异质性P值=0.726），而非高加索人。
结论
我们的结果表明，mir-196a-2 C>T多态性与CRC无总体风险关联。然而，这种多态性在亚洲人群中与风险增加相关。
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