miR-146a、miR-196a、miR-149和miR-499中的单核苷酸多态性与结直肠癌易感性的关联。
Associations of single nucleotide polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with colorectal cancer susceptibility.
作者信息
Du Wei, Ma Xue-Lei, Zhao Chong, Liu Tao, Du Yu-Liang, Kong Wei-Qi, Wei Ben-Ling, Yu Jia-Yun, Li Yan-Yan, Huang Jing-Wen, Li Zi-Kang, Liu Lei
机构信息
Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(2):1047-55. doi: 10.7314/apjcp.2014.15.2.1047.
BACKGROUND
MicroRNAs (miRNAs) are an abundant class of endogenous small non-coding RNAs of 20-25 nucleotides in length that function as negative gene regulators. MiRNAs play roles in most biological processes, as well as diverse human diseases including cancer. Recently, many studies investigated the association between SNPs in miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs229283, miR-499 rs3746444 and colorectal cancer (CRC), which results have been inconclusive.
METHODOLOGY/PRINCIPAL FINDINGS: PubMed, EMBASE, CNKI databases were searched with the last search updated on November 5, 2013. For miR-196a2 rs11614913, a significantly decreased risk of CRC development was observed under three genetic models (dominant model: OR = 0.848, 95%CI: 0.735-0.979, P = 0.025; recessive model: OR = 0.838, 95%CI: 0.721-0.974, P = 0.021; homozygous model: OR = 0.754, 95%CI: 0.627-0.907, P = 0.003). In the subgroup analyses, miR-196a2*T variant was associated with a significantly decreased susceptibility of CRC (allele model: OR = 0.839, 95%CI: 0.749-0.940, P = 0.000; dominant model: OR = 0.770, 95%CI: 0.653-0.980, P = 0.002; recessive model: OR = 0.802, 95%CI: 0.685-0.939, P = 0.006; homozygous model: OR = 0.695, 95%CI: 0.570-0.847, P = 0.000). As for miR-149 rs2292832, the two genetic models (recessive model: OR = 1.199, 95% CI 1.028-1.398, P = 0.021; heterozygous model: OR = 1.226, 95% CI 1.039-1.447, P = 0.013) demonstrated increased susceptibility to CRC. On subgroup analysis, significantly increased susceptibility of CRC was found in the genetic models (recessive model: OR = 1.180, 95% CI 1.008-1.382, P = 0.040; heterozygous model: OR = 1.202, 95% CI 1.013-1.425, P = 0.013) in the Asian group.
CONCLUSIONS
These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
背景
微小RNA（miRNA）是一类丰富的内源性小非编码RNA，长度为20 - 25个核苷酸，作为负性基因调节因子发挥作用。miRNA在大多数生物学过程以及包括癌症在内的多种人类疾病中发挥作用。最近，许多研究调查了miR - 146a rs2910164、miR - 196a2 rs11614913、miR - 149 rs229283、miR - 499 rs3746444中的单核苷酸多态性（SNP）与结直肠癌（CRC）之间的关联，但其结果尚无定论。
方法/主要发现：检索了PubMed、EMBASE、中国知网数据库，最后一次检索更新于2013年11月5日。对于miR - 196a2 rs11614913，在三种遗传模型下观察到CRC发生风险显著降低（显性模型：OR = 0.848，95%CI：0.735 - 0.979，P = 0.025；隐性模型：OR = 0.838，95%CI：0.721 - 0.974，P = 0.021；纯合子模型：OR = 0.754，95%CI：0.627 - 0.907，P = 0.003）。在亚组分析中，miR - 196a2*T变异与CRC易感性显著降低相关（等位基因模型：OR = 0.839，95%CI：0.749 - 0.940，P = 0.000；显性模型：OR = 0.770，95%CI：0.653 - 0.980，P = 0.002；隐性模型：OR = 0.802，95%CI：0.685 - 0.939，P = 0.006；纯合子模型：OR = 0.695，95%CI：0.570 - 0.847，P = 0.000）。至于miR - 149 rs2292832，两种遗传模型（隐性模型：OR = 1.199，95%CI 1.028 - 1.398，P = 0.021；杂合子模型：OR = 1.226，95%CI 1.039 - 1.447，P = 0.013）显示CRC易感性增加。在亚组分析中，在亚洲人群的遗传模型中发现CRC易感性显著增加（隐性模型：OR = 1.180，95%CI 1.008 - 1.382，P = 0.040；杂合子模型：OR = 1.202，95%CI 1.013 - 1.425，P = 0.013）。
结论
这些发现支持miR - 196a2 rs11614913和miR - 149 rs2292832多态性可能与CRC易感性有关。
Zotero 插件