Musik Irena, Kocot Joanna, Kiełczykowska Małgorzata
Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
Pharmacol Rep. 2015 Jun;67(3):446-50. doi: 10.1016/j.pharep.2014.11.010. Epub 2014 Dec 2.
Selenium is an essential element of antioxidant properties. Lithium is widely used in medicine but its administration can cause numerous side effects including oxidative stress. The present study aimed at evaluating if sodium selenite could influence chosen anti- and pro-oxidant parameters in rats treated with lithium.
The experiment was performed on four groups of Wistar rats: I (control) - treated with saline; II (Li) - treated with lithium (2.7 mgLi/kg b.w. as Li2CO3), III (Se) - treated with selenium (0.5 mgSe/kg b.w. as Na2SeO3), IV (Li+Se) - treated with Li2CO3 and Na2SeO3 together at the same doses as in group II and III, respectively. All treatments were performed by stomach tube for three weeks in form of water solutions. The following anti- and pro-oxidant parameters: total antioxidant status (TAS) value, catalase (CAT) activity, concentrations of ascorbic acid (AA) and malonyldialdehyde (MDA) in plasma as well as whole blood superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured.
Selenium given alone markedly enhanced whole blood GPx and diminished plasma CAT vs.
Lithium significantly decreased plasma CAT and slightly increased AA vs.
Selenium co-administration restored these parameters to the values observed in control animals. Furthermore, selenium co-administration significantly increased GPx in Li-treated rats. All other parameters (TAS, SOD and MDA) were not affected by lithium and/or selenium.
Further research seems to be warranted to decide if application of selenium as an adjuvant in lithium therapy is worth considering.
硒是一种具有抗氧化特性的必需元素。锂在医学中广泛应用，但其给药可引起包括氧化应激在内的多种副作用。本研究旨在评估亚硒酸钠是否会影响锂处理大鼠中选定的抗氧化和促氧化参数。
实验在四组Wistar大鼠上进行：I组（对照组）——用生理盐水处理；II组（锂组）——用锂（2.7 mgLi/kg体重，以Li2CO3形式）处理，III组（硒组）——用硒（0.5 mgSe/kg体重，以Na2SeO3形式）处理，IV组（锂+硒组）——分别以与II组和III组相同的剂量同时用Li2CO3和Na2SeO3处理。所有处理均通过胃管以水溶液形式进行三周。测量以下抗氧化和促氧化参数：总抗氧化状态（TAS）值、过氧化氢酶（CAT）活性、血浆中抗坏血酸（AA）和丙二醛（MDA）的浓度以及全血超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性。
单独给予硒显著增强了全血GPx活性，并使血浆CAT活性降低，与对照组相比：锂显著降低了血浆CAT活性，并使AA略有增加，与对照组相比：联合给予硒使这些参数恢复到对照组动物中观察到的值。此外，联合给予硒显著增加了锂处理大鼠中的GPx活性。所有其他参数（TAS、SOD和MDA）均未受到锂和/或硒的影响。
似乎有必要进行进一步研究，以确定在锂治疗中应用硒作为佐剂是否值得考虑。
