Chair and Department of Medical Chemistry, Medical University of Lublin, Lublin, Poland.
Chair and Department of Bromatology, Medical University of Lublin, Lublin, Poland.
Pharmacol Rep. 2018 Dec;70(6):1168-1172. doi: 10.1016/j.pharep.2018.05.003. Epub 2018 May 17.
Selenium is an essential element which shows protective properties against diverse harmful factors. Lithium compounds are widely used in medicine, but, in spite of undoubted beneficial effects, treatment with these compounds may lead to severe side effects, including renal, gastrointestinal, neurological, endocrine and metabolic disorders. This study was aimed at evaluating the influence of selenium and/or lithium on lithium, iron, zinc and copper content in rats' erythrocytes as well as estimate the action of additional selenium on lithium exposure effects.
The experiment was performed on four groups of rats (six animals each): control - received saline; Li - received 2.7mg Li/kg b.w. as lithium carbonate; Se - received 0.5mg Se/kg b.w. as sodium selenite; Se+Li - received simultaneously 0.5mg Se/kg b.w. and 2.7mg Li/kg b.w. (sodium selenite and lithium carbonate). The administration was performed for three weeks, once a day by stomach tube, in form of water solutions. In erythrocytes the content of lithium, iron, zinc and copper was determined using flame atomic absorption spectroscopy.
Lithium treatment insignificantly disturbed iron and zinc homeostasis as well as markedly increased lithium accumulation and copper content in rat erythrocytes. Selenium coadministration reversed those effects.
The beneficial effect of selenium on disturbances of studied microelements homeostasis as well as on preventing lithium accumulation in erythrocytes in Li receiving animals allows suggesting that further research on selenium application as an adjuvant in lithium therapy is worth carrying on.
硒是一种必需元素，具有抵抗多种有害因素的保护特性。锂化合物在医学中广泛应用，但尽管具有明显的有益作用，这些化合物的治疗可能会导致严重的副作用，包括肾脏、胃肠道、神经、内分泌和代谢紊乱。本研究旨在评估硒和/或锂对大鼠红细胞中锂、铁、锌和铜含量的影响，并评估额外的硒对锂暴露效应的作用。
该实验在四组大鼠（每组 6 只）中进行：对照组 - 给予生理盐水；Li 组 - 给予 2.7mg Li/kg.bw.作为碳酸锂；Se 组 - 给予 0.5mg Se/kg.bw.作为亚硒酸钠；Se+Li 组 - 同时给予 0.5mg Se/kg.bw.和 2.7mg Li/kg.bw.（亚硒酸钠和碳酸锂）。给药方式为每天一次通过胃管，以水溶液的形式进行，共进行三周。采用火焰原子吸收光谱法测定红细胞中锂、铁、锌和铜的含量。
锂处理对铁和锌的内稳态影响不大，但显著增加了锂在大鼠红细胞中的积累和铜的含量。硒的联合给药逆转了这些影响。
硒对研究中小分子元素内稳态紊乱的有益影响以及对防止锂在接受锂的动物的红细胞中积累的作用，提示进一步研究硒作为锂治疗的辅助剂的应用是值得进行的。
