Rospond Bartłomiej, Szpigiel Joanna, Sadakierska-Chudy Anna, Filip Małgorzata
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Kraków, Poland.
Laboratory of Drug Addiction Pharmacology, Institute of pharmacology, Polish Academy of Sciences, Kraków, Poland.
Pharmacol Rep. 2015 Jun;67(3):504-12. doi: 10.1016/j.pharep.2014.11.012. Epub 2014 Dec 8.
Obesity is a globally widespread disease. Approximately 35% of world population has the problem of inappropriate body weight due to sedentary lifestyle, excessive food consumption and the lack of physical activity. In the course of many years, several pharmacological anti-obesity drugs have been discovered. Most of them, however, possess severe side effects. Recent findings suggest that disturbed functioning of the reward system can be involved in the development of obesity. The data coming from clinical and animal studies provide new evidence that links excessive food consumption with compulsive behavior that can lead to binge eating disease occurrence. In this review we discuss most commonly used animal models of binge eating such as restriction/refeeding, limited access and stress schedule model, and related to them neurobiological findings as well. We also present new, anti-obesity drugs, which are characterized by central mechanism of action.
肥胖是一种全球广泛存在的疾病。由于久坐不动的生活方式、过度饮食和缺乏体育活动，约35%的世界人口存在体重不当问题。多年来，已发现了几种抗肥胖的药物。然而，它们中的大多数都有严重的副作用。最近的研究结果表明，奖赏系统功能紊乱可能与肥胖的发生有关。来自临床和动物研究的数据提供了新的证据，将过度饮食与可能导致暴饮暴食症发生的强迫行为联系起来。在这篇综述中，我们讨论了最常用的暴饮暴食动物模型，如限制/再喂养、限量进食和应激时间表模型，以及与之相关的神经生物学研究结果。我们还介绍了具有中枢作用机制的新型抗肥胖药物。
