Unit of Nephrology-Dialysis, Urology and Renal Transplantation, IRCCS Fondazione Ca' Granda-Ospedale Maggiore-Policlinico, Milano, Italy.
Nephrol Dial Transplant. 2016 May;31(5):730-6. doi: 10.1093/ndt/gfv098. Epub 2015 May 2.
Chronic metabolic acidosis (CMA) is a common complication of the more advanced stages of chronic kidney diseases (CKD), and is associated with morbidity and mortality of CKD patients and possibly with the progression of renal disease. Nevertheless, there is limited evidence or information on the prevalence, the potential causal factors, the clinical impact and the effects of correction of CMA in kidney transplant recipients. In this review, we briefly look at the more relevant, though scanty, studies which have, over time, addressed the above-mentioned points, with the hope that in the future the interest of transplant nephrologists and surgeons will grow towards this unreasonably neglected issue.
慢性代谢性酸中毒（CMA）是慢性肾脏病（CKD）更晚期的常见并发症，与 CKD 患者的发病率和死亡率相关，并且可能与肾脏疾病的进展相关。然而，关于移植受者中 CMA 的患病率、潜在的因果因素、临床影响和纠正效果，相关证据或信息有限。在这篇综述中，我们简要回顾了一些更相关的研究，这些研究虽然数量有限，但随着时间的推移，已经涉及了上述问题，希望未来移植肾脏病学家和外科医生会对这个被严重忽视的问题产生兴趣。
