Będkowska Grażyna Ewa, Ławicki Sławomir, Gacuta Ewa, Pawłowski Przemysław, Szmitkowski Maciej
Department of Haematological Diagnostics, Medical University, Białystok, Poland.
Department of Biochemical Diagnostics, Medical University Białystok, Waszyngtona 15A, Białystok, 15-269, Poland.
J Ovarian Res. 2015 May 3;8:27. doi: 10.1186/s13048-015-0153-3.
We investigated plasma levels of M-CSF and conventional tumor markers (HE4 and CA 125) in epithelial ovarian cancer patients as compared to control groups: benign ovarian tumor patients (cysts) and healthy subjects.
M-CSF levels were determined by ELISA, HE4 and CA 125 levels - by CMIA method.
Our results have demonstrated significant differences in the concentration levels of M-CSF, CA 125 and HE4 between the groups of ovarian cancer patients, cysts patients and the healthy controls. In the groups tested M-CSF demonstrated equal to or higher values than both CA 125 and HE4 in diagnostic sensitivity (SE), positive and negative predictive values (PPV, NPV), and in the area under the ROC curve (AUC), particularly in the group with the serous epithelial sub-type of OC. Moreover, CA 125 showed better results of the aforementioned diagnostic criteria than HE4. The combined use of the parameters studied resulted in a further, significant increase in the value of the diagnostic indicators and in the value of the diagnostic power (AUC), especially in the early stages of ovarian cancer.
These findings suggest a high usefulness of M-CSF in diagnosing the serous sub-type of epithelial ovarian cancer and in discriminating between cancer and non-carcinoma lesions, particularly in new diagnostic panels in combination with CA 125 and HE4 for the detection of EOC in the early stages.
我们研究了上皮性卵巢癌患者与对照组（良性卵巢肿瘤患者（囊肿）和健康受试者）相比的血浆M-CSF水平及传统肿瘤标志物（HE4和CA 125）水平。
采用ELISA法测定M-CSF水平，采用CMIA法测定HE4和CA 125水平。
我们的结果表明，卵巢癌患者组、囊肿患者组和健康对照组之间M-CSF、CA 125和HE4的浓度水平存在显著差异。在所测试的组中，M-CSF在诊断敏感性（SE）、阳性和阴性预测值（PPV、NPV）以及ROC曲线下面积（AUC）方面显示出等于或高于CA 125和HE4的值，特别是在浆液性上皮亚型OC组中。此外，CA 125在上述诊断标准方面比HE4表现更好。所研究参数的联合使用导致诊断指标的值和诊断能力的值（AUC）进一步显著增加，尤其是在卵巢癌的早期阶段。
这些发现表明M-CSF在诊断浆液性上皮性卵巢癌亚型以及区分癌症和非癌性病变方面具有很高的实用性，特别是在与CA 125和HE4联合用于早期检测EOC的新诊断组合中。
