Nyc Otakar, Krutova Marcela, Kriz Jiri, Matejkova Jana, Bebrova Eliska, Hysperska Veronika, Kuijper Ed J
Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, 150 06, Prague 5, Czech Republic.
DNA Laboratory, Department of Child Neurology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Folia Microbiol (Praha). 2015 Nov;60(6):541-4. doi: 10.1007/s12223-015-0392-0. Epub 2015 May 3.
Extra-intestinal infections caused by Clostridium difficile are rare. The risk of extra-intestinal infections associated with C. difficile may be particularly relevant in environments contaminated with C. difficile spores. This paper describes the case of a non-diarrheic patient colonized with C. difficile ribotype 014 in the intestinal tract who developed a post-surgical wound infection by C. difficile ribotype 078. The infection responded to metronidazole administered first intravenously and then orally. This case indicates that C. difficile may not only be related to diarrheic diseases, but also to infections of non-healing wounds, especially in situations when C. difficile is the only isolated pathogen.
艰难梭菌引起的肠道外感染较为罕见。在被艰难梭菌孢子污染的环境中,与艰难梭菌相关的肠道外感染风险可能尤为突出。本文描述了一例肠道定植有014型艰难梭菌的非腹泻患者,术后伤口发生了078型艰难梭菌感染。该感染对先静脉后口服的甲硝唑治疗有效。此病例表明,艰难梭菌不仅可能与腹泻疾病有关,还可能与不愈合伤口的感染有关,尤其是在艰难梭菌是唯一分离出的病原体的情况下。