Al-Amri Fahad A, Saeedi Mohammed Y, Al-Tahan Fatina M, Ali Arwa M, Alomary Shaker A, Arafa Mostafa, Ibrahim Ahmed K, Kassim Kassim A
Ministry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi Arabia.
King Khalid University Hospitals, Medical Oncology Department, King Saud University, Saudi Arabia; Medical Oncology Department, South Egypt Cancer Institute, Assiut University, Asyut, Egypt.
J Egypt Natl Canc Inst. 2015 Jun;27(2):77-82. doi: 10.1016/j.jnci.2015.04.002. Epub 2015 Apr 29.
Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others.
We aimed to identify the different risk factors related to breast cancer among females participating in the breast-screening program in Riyadh, KSA.
Based on data from phase-I of the breast-screening program, a case-control study was conducted on women living in Riyadh, KSA. A sample of 349 women (58 cases and 290 controls) was recruited to examine the different breast cancer correlates. Multivariate regression model was built to investigate the most important risk factors.
The mean age of cases was 48.5±7.1 years. Age at marriage, number of pregnancy, age at menopause, oral contraceptive pills, breast feeding and family history of breast cancer in first-degree relative were identified as the most important correlates among the studied cohort.
The findings of the current work suggested that age at marriage, age at menopause ⩾50 years and 1st degree family history of breast cancer were risk factors for breast cancer, while, age at menopause <50 years, number of pregnancies and practicing breast feeding were protective factors against breast cancer. There was no effect of body mass index or physical inactivity. Further studies are needed to explore the hereditary, familial and genetic background risk factors in Saudi population.
乳腺癌是沙特阿拉伯王国女性中的首要癌症，在2010年新诊断的女性癌症中占27.4%。有几个影响乳腺癌发病率的风险因素，其中一些因素对风险的影响大于其他因素。
我们旨在确定沙特阿拉伯利雅得参加乳腺癌筛查项目的女性中与乳腺癌相关的不同风险因素。
基于乳腺癌筛查项目第一阶段的数据，对居住在沙特阿拉伯利雅得的女性进行了病例对照研究。招募了349名女性（58例病例和290名对照）样本，以检查不同的乳腺癌相关因素。建立多变量回归模型以研究最重要的风险因素。
病例的平均年龄为48.5±7.1岁。结婚年龄、怀孕次数、绝经年龄、口服避孕药、母乳喂养以及一级亲属的乳腺癌家族史被确定为研究队列中最重要的相关因素。
当前研究结果表明，结婚年龄、绝经年龄⩾50岁以及乳腺癌一级家族史是乳腺癌的风险因素，而绝经年龄<50岁、怀孕次数和进行母乳喂养是预防乳腺癌的保护因素。体重指数或缺乏身体活动没有影响。需要进一步研究以探索沙特人群中的遗传、家族和基因背景风险因素。
