AlFaris Nora A, ALkehayez Nora M, AlMushawah Fatema I, Al Naeem AbdulRhman N, Al-Amri Nadia D, Almudawah Ebtisam S
Nutrition and Food Science, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2018 Jun;39(6):564-571. doi: 10.15537/smj.2018.6.21902.
To assess the role of serum vitamin D and other nutritional factors in women with breast cancer in Saudi.
A total of 500 women (250 patients with breast cancer and 250 controls) aged 30-60 years were recruited from King Saud Medical City and King Fahad Medical City, Riyadh, Saudi Arabia, between May 2015 and June 2016. In this cross-sectional study, blood pressure, plasma concentrations of vitamin D, and calcium levels were evaluated. A 3-day dietary record was used to assess dietary intake.
The mean body mass index was 31.2±7.0 kg/m2 for the breast cancer group and 30.7±7.6 kg/m2 for the control group. More than 80% of the participants had insufficient vitamin D levels (less than 75.0 nmol/L). The mean cholesterol intake was significantly (p=0.001) lower in the control group (233.1±75.1 mg) than in the breast cancer group (257.2±84.8 mg). Breast density was found to be significantly associated with vitamin D deficiency-symptoms. Severe paresthesia was also significantly associated with breast cancer. The incidence of other vitamin D deficiency-symptoms was significantly higher in the control group.
Due to prevalence of vitamin D deficiency in Saudi Arabia, it is difficult to determine the relationship to breast cancer. The incidence of it is associated with old age and high cholesterol intake, and paresthesia may be a symptom of breast cancer.
评估血清维生素D及其他营养因素在沙特乳腺癌女性中的作用。
2015年5月至2016年6月期间，从沙特利雅得的沙特国王医疗城和法赫德国王医疗城招募了500名年龄在30至60岁之间的女性（250例乳腺癌患者和250名对照）。在这项横断面研究中，评估了血压、维生素D的血浆浓度和钙水平。采用3天饮食记录来评估饮食摄入量。
乳腺癌组的平均体重指数为31.2±7.0kg/m²，对照组为30.7±7.6kg/m²。超过80%的参与者维生素D水平不足（低于75.0nmol/L）。对照组的平均胆固醇摄入量（233.1±75.1mg）显著低于乳腺癌组（257.2±84.8mg）（p=0.001）。发现乳腺密度与维生素D缺乏症状显著相关。严重感觉异常也与乳腺癌显著相关。对照组中其他维生素D缺乏症状的发生率显著更高。
由于沙特阿拉伯维生素D缺乏的普遍性，难以确定其与乳腺癌的关系。其发生率与老年和高胆固醇摄入量有关，感觉异常可能是乳腺癌的一种症状。
