Ozbay I, Kahraman C, Balikci H H, Kucur C, Kahraman N K, Ozkaya D P, Oghan F
Department of Otorhinolaryngology,Dumlupınar University,Kutahya.
Department of Internal Medicine,Dumlupınar University Evliya Celebi Education and Research Hospital,Kutahya.
J Laryngol Otol. 2015 Jun;129(6):544-7. doi: 10.1017/S0022215115000845. Epub 2015 May 4.
To determine the relationship between severe tinnitus and inflammation using the neutrophil-to-lymphocyte ratio as a marker of stress.
A total of 107 patients who had been suffering with severe tinnitus (tinnitus handicap inventory scale grades of 3-5) for at least 2 weeks were recruited. Patients underwent detailed ENT examinations and audiometric tests to exclude a relevant pathological cause of the tinnitus. Patients with systemic diseases, malignancy or inflammatory diseases that could alter neutrophil-to-lymphocyte ratio were excluded. A total of 107 age- and sex-matched healthy control participants were also recruited. Routine laboratory test results and neutrophil-to-lymphocyte ratio were compared between the patients and controls.
Lipid profile, liver function, white blood cell count, haemoglobin level, mean corpuscular volume, and vitamin B12 and folate levels were similar among the patients and controls. However, mean neutrophil-to-lymphocyte ratio was significantly higher among the patients than the controls (p < 0.05).
The findings of this novel study suggest that neutrophil-to-lymphocyte ratio should be considered during the evaluation of tinnitus patients as a potential clinical marker of tinnitus. Further studies are required to verify the findings.
以中性粒细胞与淋巴细胞比值作为应激指标，确定重度耳鸣与炎症之间的关系。
共招募了107例患有重度耳鸣（耳鸣致残量表评分为3 - 5级）至少2周的患者。患者接受了详细的耳鼻喉科检查和听力测试，以排除耳鸣的相关病理原因。排除患有可能改变中性粒细胞与淋巴细胞比值的全身性疾病、恶性肿瘤或炎症性疾病的患者。还招募了107名年龄和性别匹配的健康对照参与者。比较患者和对照组的常规实验室检查结果及中性粒细胞与淋巴细胞比值。
患者和对照组之间的血脂谱、肝功能、白细胞计数、血红蛋白水平、平均红细胞体积以及维生素B12和叶酸水平相似。然而，患者的平均中性粒细胞与淋巴细胞比值显著高于对照组（p < 0.05）。
这项新研究的结果表明，在评估耳鸣患者时应考虑中性粒细胞与淋巴细胞比值，将其作为耳鸣潜在的临床指标。需要进一步研究来验证这些发现。
