Moris Demetrios, Georgopoulos Sotirios, Felekouras Evangelos, Patsouris Efstratios, Theocharis Stamatios
National and Kapodistrian University of Athens , Anastasiou Gennadiou 56, 11474, Athens , Greece +30 210 6440590 ;
Expert Opin Ther Targets. 2015;19(9):1261-75. doi: 10.1517/14728222.2015.1043268. Epub 2015 May 2.
In recent years, the endocannabinoid system has emerged as a new therapeutic target in variety of disorders associated with inflammation and tissue injury, including those of the neuronal, liver, renal and cardiovascular system. The aim of the present review is to elucidate the effect of endocannabinoid system on ischemia reperfusion injury (IRI) in different organs and systems.
The MEDLINE/PubMed database was searched for publications with the medical subject heading Cannabinoids* (CBs), CB receptors*, organ*, ischemia/reperfusion injury*, endocannabinoid* and system*. The initial relevant studies retrieved from the literature were 91 from PubMed. This number was initially limited to 35, after excluding the reviews and studies reporting data for receptors other than cannabinoid.
CB2 receptors may play an important compensatory role in controlling tissue inflammation and injury in cells of the neuronal, cardiovascular, liver and renal systems, as well as in infiltrating monocytes/macrophages and leukocytes during various pathological conditions of the systems (atherosclerosis, restenosis, stroke, myocardial infarction, heart, liver and renal failure). These receptors limit inflammation and associated tissue injury. On the basis of preclinical results, pharmacological modulation of CB2 receptors may hold a unique therapeutic potential in stroke, myocardial infarction, atherosclerosis, IRI and liver disease.
近年来，内源性大麻素系统已成为多种与炎症和组织损伤相关疾病的新治疗靶点，包括神经元、肝脏、肾脏和心血管系统疾病。本综述的目的是阐明内源性大麻素系统对不同器官和系统缺血再灌注损伤（IRI）的影响。
在MEDLINE/PubMed数据库中检索了以医学主题词大麻素*（CBs）、CB受体*、器官*、缺血/再灌注损伤*、内源性大麻素和系统发表的文献。从文献中检索到的最初相关研究有91篇来自PubMed。在排除综述和报告除大麻素受体以外其他受体数据的研究后，这个数字最初限制为35篇。
CB2受体可能在控制神经元、心血管、肝脏和肾脏系统细胞以及这些系统各种病理状况（动脉粥样硬化、再狭窄、中风、心肌梗死、心脏、肝脏和肾衰竭）期间浸润的单核细胞/巨噬细胞和白细胞的组织炎症和损伤方面发挥重要的代偿作用。这些受体限制炎症和相关的组织损伤。基于临床前结果，CB2受体的药理学调节可能在中风、心肌梗死、动脉粥样硬化、IRI和肝病方面具有独特的治疗潜力。
