Wan Guoqiang, Corfas Gabriel
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Hear Res. 2015 Nov;329:1-10. doi: 10.1016/j.heares.2015.04.008. Epub 2015 Apr 30.
Cochlear ribbon synapses are required for the rapid and precise neural transmission of acoustic signals from inner hair cells to the spiral ganglion neurons. Emerging evidence suggests that damage to these synapses represents an important form of cochlear neuropathy that might be highly prevalent in sensorineural hearing loss. In this review, we discuss our current knowledge on how ribbon synapses are damaged by noise and during aging, as well as potential strategies to promote ribbon synapse regeneration for hearing restoration.
耳蜗带状突触对于将声音信号从内毛细胞快速、精确地神经传递到螺旋神经节神经元是必需的。新出现的证据表明，这些突触的损伤是耳蜗神经病变的一种重要形式，在感音神经性听力损失中可能非常普遍。在这篇综述中，我们讨论了目前关于带状突触如何在噪声暴露和衰老过程中受损的知识，以及促进带状突触再生以恢复听力的潜在策略。
