De Dipankar, Khullar Geeti, Handa Sanjeev
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol Venereol Leprol. 2015 Jul-Aug;81(4):376-9. doi: 10.4103/0378-6323.156199.
Parthenium hysterophorus is the leading cause of phytogenic allergic contact dermatitis in India. The Indian Standard Series currently supplied by Systopic Laboratories Ltd and manufactured by Chemotechnique Diagnostics ® contains parthenolide as the only allergen representing plant allergens.
The study was conducted to assess the performance of the Chemotechnique plant series (PL-1000), consisting of 14 allergens, in patients with clinically suspected occupational contact dermatitis to plant allergens.
Ninety patients were patch tested with the Chemotechnique plant series from 2011 to 2013. Demographic details, clinical diagnosis and patch test results were recorded in the contact dermatitis clinic proforma.
Of 90 patients, 24 (26.7%) showed positive reactions to one or more allergens in the plant series. Positive patch tests were elicited most commonly by sesquiterpene lactone mix in 19 (78.6%) patients, followed by parthenolide in 14 (57.1%), Achillea millefolium in 10 (42.9%) and others in decreasing order.
The plant allergen series prepared by Chemotechnique Diagnostics is possibly not optimal for diagnosing suspected allergic contact dermatitis to plants in north Indians. Sesquiterpene lactone mix should replace parthenolide as the plant allergen in the Indian Standard Series until relevant native plant extracts are commercially available for patch testing.
在印度，银胶菊是植物源性过敏性接触性皮炎的主要病因。目前由Systopic Laboratories Ltd供应、Chemotechnique Diagnostics®生产的印度标准系列产品包含小白菊内酯作为唯一代表植物过敏原的过敏原。
本研究旨在评估由14种过敏原组成的Chemotechnique植物系列（PL - 1000）在临床疑似职业性植物过敏原接触性皮炎患者中的性能。
2011年至2013年，对90例患者进行了Chemotechnique植物系列的斑贴试验。在接触性皮炎诊所表格中记录人口统计学细节、临床诊断和斑贴试验结果。
90例患者中，24例（26.7%）对植物系列中的一种或多种过敏原呈阳性反应。阳性斑贴试验最常见的诱发物是倍半萜内酯混合物，有19例（78.6%）患者出现，其次是小白菊内酯，有14例（57.1%），蓍草有10例（42.9%），其他依次递减。
Chemotechnique Diagnostics制备的植物过敏原系列可能并非诊断北印度人疑似植物过敏性接触性皮炎的最佳选择。在有相关本土植物提取物可用于斑贴试验之前，倍半萜内酯混合物应取代小白菊内酯作为印度标准系列中的植物过敏原。
