• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单细胞端粒长度定量将拟南芥中的端粒长度与分生组织活性及干细胞发育联系起来。

Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis.

作者信息

González-García Mary-Paz, Pavelescu Irina, Canela Andrés, Sevillano Xavier, Leehy Katherine A, Nelson Andrew D L, Ibañes Marta, Shippen Dorothy E, Blasco Maria A, Caño-Delgado Ana I

机构信息

Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Barcelona 08193, Spain; Centro Nacional de Biotecnología (CSIC), Cantoblanco, 28049 Madrid, Spain.

Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Barcelona 08193, Spain; Department of Structure and Constituents of Matter, Faculty of Physics, University of Barcelona, Barcelona 08024, Spain.

出版信息

Cell Rep. 2015 May 12;11(6):977-989. doi: 10.1016/j.celrep.2015.04.013. Epub 2015 Apr 30.

DOI:10.1016/j.celrep.2015.04.013
PMID:25937286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4827700/
Abstract

Telomeres are specialized nucleoprotein caps that protect chromosome ends assuring cell division. Single-cell telomere quantification in animals established a critical role for telomerase in stem cells, yet, in plants, telomere-length quantification has been reported only at the organ level. Here, a quantitative analysis of telomere length of single cells in Arabidopsis root apex uncovered a heterogeneous telomere-length distribution of different cell lineages showing the longest telomeres at the stem cells. The defects in meristem and stem cell renewal observed in tert mutants demonstrate that telomere lengthening by TERT sets a replicative limit in the root meristem. Conversely, the long telomeres of the columella cells and the premature stem cell differentiation plt1,2 mutants suggest that differentiation can prevent telomere erosion. Overall, our results indicate that telomere dynamics are coupled to meristem activity and continuous growth, disclosing a critical association between telomere length, stem cell function, and the extended lifespan of plants.

摘要

端粒是一种特殊的核蛋白帽，可保护染色体末端以确保细胞分裂。动物单细胞端粒定量研究确定了端粒酶在干细胞中的关键作用，然而，在植物中，仅在器官水平报道过端粒长度定量分析。在这里，对拟南芥根尖单细胞端粒长度的定量分析发现，不同细胞谱系的端粒长度分布不均一，干细胞中的端粒最长。在tert突变体中观察到的分生组织和干细胞更新缺陷表明，TERT介导的端粒延长为根分生组织设定了复制极限。相反，柱细胞的长端粒以及plt1、2突变体中干细胞的过早分化表明，分化可以防止端粒侵蚀。总体而言，我们的结果表明端粒动态与分生组织活性和持续生长相关联，揭示了端粒长度、干细胞功能与植物延长寿命之间的关键联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/40c8db7d3f52/nihms769270f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/48d7bde2b1ff/nihms769270f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/5a0a6f180706/nihms769270f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/028a2f0466f3/nihms769270f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/2dc635283fcd/nihms769270f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/45651b6caadb/nihms769270f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/40c8db7d3f52/nihms769270f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/48d7bde2b1ff/nihms769270f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/5a0a6f180706/nihms769270f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/028a2f0466f3/nihms769270f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/2dc635283fcd/nihms769270f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/45651b6caadb/nihms769270f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dec3/4827700/40c8db7d3f52/nihms769270f6.jpg

相似文献

1
Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis.单细胞端粒长度定量将拟南芥中的端粒长度与分生组织活性及干细胞发育联系起来。
Cell Rep. 2015 May 12;11(6):977-989. doi: 10.1016/j.celrep.2015.04.013. Epub 2015 Apr 30.
2
Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.拟南芥AN3和OLIGOCELLULA基因将端粒维持机制与细胞分裂和扩展控制联系起来。
Plant Mol Biol. 2024 May 30;114(3):65. doi: 10.1007/s11103-024-01457-6.
3
MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.分生组织紊乱 1 编码 TEN1，这是一种必需的端粒蛋白，可调节拟南芥中端粒酶的进程。
Plant Cell. 2013 Apr;25(4):1343-54. doi: 10.1105/tpc.112.107425. Epub 2013 Apr 9.
4
Spatial coordination between stem cell activity and cell differentiation in the root meristem.根分生组织中干细胞活性和细胞分化的空间协调。
Dev Cell. 2013 Aug 26;26(4):405-15. doi: 10.1016/j.devcel.2013.06.025.
5
APETALA2 regulates the stem cell niche in the Arabidopsis shoot meristem.APETALA2调控拟南芥茎尖分生组织中的干细胞微环境。
Plant Cell. 2006 Feb;18(2):295-307. doi: 10.1105/tpc.105.038398. Epub 2005 Dec 30.
6
ULTRAPETALA1 maintains Arabidopsis root stem cell niche independently of ARABIDOPSIS TRITHORAX1.ULTRAPETALA1 独立于拟南芥 TRITHORAX1 维持拟南芥根干细胞壁龛。
New Phytol. 2020 Feb;225(3):1261-1272. doi: 10.1111/nph.16213. Epub 2019 Oct 28.
7
PRL1 modulates root stem cell niche activity and meristem size through WOX5 and PLTs in Arabidopsis.PRL1 通过 WOX5 和 PLTs 调节拟南芥根干细胞龛活性和分生组织大小。
Plant J. 2015 Feb;81(3):399-412. doi: 10.1111/tpj.12733. Epub 2014 Dec 22.
8
Organizer-Derived WOX5 Signal Maintains Root Columella Stem Cells through Chromatin-Mediated Repression of CDF4 Expression.组织者衍生的 WOX5 信号通过染色质介导的 CDF4 表达抑制来维持根冠柱干细胞。
Dev Cell. 2015 Jun 8;33(5):576-88. doi: 10.1016/j.devcel.2015.04.024. Epub 2015 May 28.
9
Intersected functional zone of transcriptional regulators patterns stemness within stem cell niche of root apical meristem.转录调控因子的交汇功能区模式在根顶端分生组织干细胞生态位中维持干细胞特性。
J Integr Plant Biol. 2020 Jul;62(7):897-911. doi: 10.1111/jipb.12881. Epub 2020 Mar 2.
10
Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers.保守因子调控拟南芥地上部和根部干细胞组织中心的信号传导。
Nature. 2007 Apr 12;446(7137):811-4. doi: 10.1038/nature05703.

引用本文的文献

1
Telomeres: an organized string linking plants and mammals.端粒：连接植物和哺乳动物的有序字符串。
Biol Direct. 2024 Nov 20;19(1):119. doi: 10.1186/s13062-024-00558-y.
2
Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.拟南芥AN3和OLIGOCELLULA基因将端粒维持机制与细胞分裂和扩展控制联系起来。
Plant Mol Biol. 2024 May 30;114(3):65. doi: 10.1007/s11103-024-01457-6.
3
Telomere dynamics and oxidative stress in Arabidopsis grown in lunar regolith simulant.拟南芥在月球风化层模拟物中生长时的端粒动态与氧化应激

本文引用的文献

1
Regulation of plant stem cell quiescence by a brassinosteroid signaling module.植物干细胞静止期由油菜素内酯信号模块调控。
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020. Epub 2014 Jun 26.
2
A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.SCARECROW-RETINOBLASTOMA 蛋白网络控制拟南芥根干细胞组织者中的保护性静止。
PLoS Biol. 2013 Nov;11(11):e1001724. doi: 10.1371/journal.pbio.1001724. Epub 2013 Nov 26.
3
The hallmarks of aging.衰老的特征。
Front Plant Sci. 2024 Feb 16;15:1351613. doi: 10.3389/fpls.2024.1351613. eCollection 2024.
4
Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space.拟南芥端粒酶通过在空间中使酶活性与端粒长度维持解耦而起飞。
Nat Commun. 2023 Nov 29;14(1):7854. doi: 10.1038/s41467-023-41510-4.
5
Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.拟南芥AN3和OLIGOCELLULA基因将端粒维持机制与细胞分裂及扩展控制联系起来。
Res Sq. 2023 Oct 28:rs.3.rs-3438810. doi: 10.21203/rs.3.rs-3438810/v1.
6
Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China.哪些因素影响健康衰老？来自中国巴马长寿村的启示。
Aging Dis. 2023 Jun 1;14(3):825-839. doi: 10.14336/AD.2022.1108.
7
A Journey to the Core of the Plant Cell Cycle.植物细胞周期的核心之旅。
Int J Mol Sci. 2022 Jul 24;23(15):8154. doi: 10.3390/ijms23158154.
8
Searching for the link between telomere length and life history traits in plants.探寻植物端粒长度与生活史特征之间的联系。
Plant Cell. 2021 May 31;33(4):1087-1088. doi: 10.1093/plcell/koab040.
9
Unraveling Root Development Through Single-Cell Omics and Reconstruction of Gene Regulatory Networks.通过单细胞组学和基因调控网络重建揭示根系发育
Front Plant Sci. 2021 May 4;12:661361. doi: 10.3389/fpls.2021.661361. eCollection 2021.
10
Natural variation in plant telomere length is associated with flowering time.植物端粒长度的自然变异与开花时间有关。
Plant Cell. 2021 May 31;33(4):1118-1134. doi: 10.1093/plcell/koab022.
Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.
4
Senescence, ageing and death of the whole plant.整株植物的衰老、老化和死亡。
New Phytol. 2013 Feb;197(3):696-711. doi: 10.1111/nph.12047. Epub 2012 Nov 23.
5
Beyond average: potential for measurement of short telomeres.超越平均水平：测量短端粒的潜力。
Aging (Albany NY). 2012 Jun;4(6):379-92. doi: 10.18632/aging.100462.
6
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.端粒酶基因治疗可延缓成年和老年小鼠衰老并延长寿命，而不增加癌症风险。
EMBO Mol Med. 2012 Aug;4(8):691-704. doi: 10.1002/emmm.201200245. Epub 2012 May 15.
7
Control of Arabidopsis root development.拟南芥根系发育的调控。
Annu Rev Plant Biol. 2012;63:563-90. doi: 10.1146/annurev-arplant-042811-105501. Epub 2012 Feb 9.
8
ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.ATR 通过与 CTC1 和 STN1 合作维持拟南芥端粒和基因组完整性。
Mol Biol Cell. 2012 Apr;23(8):1558-68. doi: 10.1091/mbc.E11-12-1002. Epub 2012 Feb 22.
9
Root development.根系发育
Arabidopsis Book. 2002;1:e0101. doi: 10.1199/tab.0101. Epub 2002 Sep 30.
10
Arabidopsis ATM and ATR kinases prevent propagation of genome damage caused by telomere dysfunction.拟南芥 ATM 和 ATR 激酶可防止端粒功能障碍引起的基因组损伤的传播。
Plant Cell. 2011 Dec;23(12):4254-65. doi: 10.1105/tpc.111.092387. Epub 2011 Dec 9.