Pakfetrat Atessa, Delavarian Zahra, Falaki Farnaz, Khorashadizadeh Mahboubeh, Saba Mina
Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Oral Medicine Specialist, DDS MSc, San Diego, USA.
Iran J Otorhinolaryngol. 2015 Mar;27(79):119-26.
Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase) with topical pimecrolimus cream for the treatment of erosive OLP.
Twenty-eight patients with OLP were enrolled in a single blind clinical trial and assigned to either a pimecrolimus 1% cream group or an adcortyl 0.1% cream group. The medication was applied every day for 2 months and patients were assessed every 2 weeks.
The mean lesion size and mean pain and burning sensation scores did not differ between the pimecrolimus and adcortyl cream groups. The pimecrolimus cream was well tolerated. No clinical drug-related adverse events were observed.
Topical pimecrolimus cream may be recommended as a safe and effective alternative therapy in the treatment of OLP. Pimecrolimus cream is as effective as adcortyl cream in managing the signs and symptoms of OLP.
口腔扁平苔藓（OLP）是一种常见的慢性黏膜皮肤疾病。萎缩型和糜烂型OLP患者常伴有疼痛症状，需要进行适当治疗。OLP的主要治疗方法一直是局部或全身使用皮质类固醇。本研究的目的是比较艾洛松乳膏（曲安奈德口腔糊剂）与局部用吡美莫司乳膏治疗糜烂型OLP的疗效。
28例OLP患者参与了一项单盲临床试验，被分为1%吡美莫司乳膏组或0.1%艾洛松乳膏组。每天用药，持续2个月，每2周对患者进行评估。
吡美莫司乳膏组和艾洛松乳膏组之间的平均病损大小、平均疼痛和烧灼感评分无差异。吡美莫司乳膏耐受性良好。未观察到与药物相关的临床不良事件。
局部用吡美莫司乳膏可作为治疗OLP的一种安全有效的替代疗法。吡美莫司乳膏在控制OLP的体征和症状方面与艾洛松乳膏效果相当。
