Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2021 Apr 15;11(1):8264. doi: 10.1038/s41598-021-87778-8.
Lichen planus is the most common skin disease that affects the oral mucosa. Oral Lichen Planus is a T-cell-mediated autoimmune disorder. In the current study, for the first time, an oral cavity condition in skin patch tests with adding saliva is simulated. In addition, the patch results are compared with healthy subjects. Forty-one OLP patients and 63 healthy subjects were enrolled in the study. All participants were provided with patch tests, including allergens, in combination with saliva in chambers. Allergens from the European baseline (standard) series selected according to the most prevalent positive results in the previous study were applied. Positive results of Mercury and Cobalt tests were significantly higher in the case group. In this study, the differentiation of patients with lichen planus and lichenoid was identified according to the Van der Meij & Van der Waal criteria. The patch test was conducted for healthy individuals as well. The most important of all was the use of patients' saliva in the patch test, done for the first time in this field. In the case of OLP, a patch test can help identify positive reactions to dental materials; thus, the replacement of dental restorations may be needed.
扁平苔藓是最常见的皮肤疾病，会影响口腔黏膜。口腔扁平苔藓是一种 T 细胞介导的自身免疫性疾病。在当前的研究中，首次模拟了在皮肤斑贴试验中加入唾液的口腔状况。此外，还将贴剂结果与健康受试者进行了比较。本研究纳入了 41 例 OLP 患者和 63 例健康受试者。所有参与者均接受了斑贴试验，包括在腔室内加入过敏原和唾液的联合斑贴试验。根据之前研究中最常见的阳性结果选择了来自欧洲基线（标准）系列的过敏原。汞和钴测试的阳性结果在病例组中显著更高。在这项研究中，根据 Van der Meij 和 Van der Waal 标准对扁平苔藓和苔藓样病变的患者进行了区分。同时也对健康个体进行了斑贴试验。最重要的是，在这项研究中首次在皮肤斑贴试验中使用了患者的唾液。在 OLP 的情况下，斑贴试验可以帮助识别对牙科材料的阳性反应，因此可能需要更换牙科修复体。
