• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

咬肌注射A型肉毒杆菌毒素对发育期大鼠下颌骨生长的影响。

Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats.

作者信息

Seok Hyun, Kim Seong-Gon, Kim Min-Keun, Jang Insan, Ahn Janghoon

机构信息

1Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju, 28644 South Korea.

2Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, 7 Jukhyun-gil, Gangneung, 25457 South Korea.

出版信息

Maxillofac Plast Reconstr Surg. 2018 Mar 25;40(1):5. doi: 10.1186/s40902-018-0146-4. eCollection 2018 Dec.

DOI:10.1186/s40902-018-0146-4
PMID:29588910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5866820/
Abstract

BACKGROUND

The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo.

METHODS

Eleven Sprague-Dawley rats were used, and BTX-A ( = 6) or saline ( = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis.

RESULTS

The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group ( < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group ( < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides ( < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side.

CONCLUSION

BTX-A injection into the masseter muscle influences mandibular bone growth.

摘要

背景

本研究的目的是评估在体内咀嚼肌注射A型肉毒杆菌毒素（BTX-A）对下颌骨生长的影响。

方法

使用11只Sprague-Dawley大鼠，在13日龄时注射BTX-A（n = 6）或生理盐水（n = 5）。所有注射均注入右侧咬肌，BTX-A剂量为0.5单位。所有大鼠在60日龄时安乐死。分离大鼠颅骨并用10%福尔马林固定，用于微型计算机断层扫描（micro-CT）分析。

结果

人体测量分析发现，注射BTX-A组的下颌支高度和下颌角宽度明显小于注射生理盐水组（P < 0.05），注射BTX-A组的下颌平面角明显大于注射生理盐水组（P < 0.001）。在注射BTX-A组中，下颌支高度II和III以及下颌平面角I和II在注射侧和未注射侧之间存在显著差异（P < 0.05）。咬肌组中注射BTX-A侧的下颌骨生长明显低于未注射侧。

结论

向咬肌注射BTX-A会影响下颌骨生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/f032399100da/40902_2018_146_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/66412928b23e/40902_2018_146_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/34f765163ddd/40902_2018_146_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/f032399100da/40902_2018_146_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/66412928b23e/40902_2018_146_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/34f765163ddd/40902_2018_146_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5ae/5866820/f032399100da/40902_2018_146_Fig3_HTML.jpg

相似文献

1
Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats.咬肌注射A型肉毒杆菌毒素对发育期大鼠下颌骨生长的影响。
Maxillofac Plast Reconstr Surg. 2018 Mar 25;40(1):5. doi: 10.1186/s40902-018-0146-4. eCollection 2018 Dec.
2
Botulinum toxin in masticatory muscles of the adult rat induces bone loss at the condyle and alveolar regions of the mandible associated with a bone proliferation at a muscle enthesis.成年大鼠咀嚼肌中的肉毒杆菌毒素会导致下颌骨髁突和牙槽区域的骨质流失，并伴有肌肉附着点处的骨质增生。
Bone. 2015 Aug;77:75-82. doi: 10.1016/j.bone.2015.03.023. Epub 2015 Apr 7.
3
Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats.A型肉毒杆菌毒素单侧注射到发育中大鼠咬肌的生长效应
J Zhejiang Univ Sci B. 2015 Jan;16(1):46-51. doi: 10.1631/jzus.B1400192.
4
Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats.成年大鼠单侧注射肉毒杆菌神经毒素后下颌骨的形态学和骨结构变化
J Oral Maxillofac Surg. 2010 May;68(5):1081-7. doi: 10.1016/j.joms.2009.12.009. Epub 2010 Mar 2.
5
Botulinum toxin in masticatory muscles: short- and long-term effects on muscle, bone, and craniofacial function in adult rabbits.咀嚼肌中的肉毒毒素：对成年兔肌肉、骨骼和颅面功能的短期和长期影响。
Bone. 2012 Mar;50(3):651-62. doi: 10.1016/j.bone.2011.11.015. Epub 2011 Dec 2.
6
Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible.注射到发育中大鼠下颌骨咬肌内的A型肉毒杆菌毒素的生长效应
Oral Dis. 2008 Oct;14(7):626-32. doi: 10.1111/j.1601-0825.2007.01435.x. Epub 2008 Mar 6.
7
Unilateral injection of botulinum toxin type A into the masseter muscle induces mandibular asymmetry in adolescent rats by suppressing the angular process growth.肉毒毒素 A 单侧注射至咬肌可通过抑制下颌角生长诱导青少年大鼠出现下颌不对称。
Am J Orthod Dentofacial Orthop. 2024 Feb;165(2):232-244. doi: 10.1016/j.ajodo.2023.09.009. Epub 2023 Oct 28.
8
Repeated unilateral injections of botulinum toxin in masticatory muscles in adult rats do not amplify condylar and alveolar bone loss nor modify the volume of the hypertrophic bone proliferation at enthesis.在成年大鼠咀嚼肌中反复单侧注射肉毒毒素不会放大髁突和牙槽骨的丢失，也不会改变附着处肥大骨增殖的体积。
J Stomatol Oral Maxillofac Surg. 2024 Sep;125(5S1):101955. doi: 10.1016/j.jormas.2024.101955. Epub 2024 Jun 29.
9
Obvious morphologic changes in the mandible and condylar cartilage after triple botulinum toxin injections into the bilateral masseter.三次双侧咬肌注射肉毒毒素后下颌骨和髁突软骨的明显形态学变化。
Am J Orthod Dentofacial Orthop. 2020 Oct;158(4):e43-e52. doi: 10.1016/j.ajodo.2020.01.017.
10
Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification.BTX 通过改变缝间骨改建影响咀嚼肌功能从而影响颌面部骨骼生长。
Orthod Craniofac Res. 2019 May;22(2):112-117. doi: 10.1111/ocr.12290. Epub 2019 Feb 5.

引用本文的文献

1
Effect of masseter hypofunction on mandibular growth and masticatory muscle coordination: an in vivo study of animal model.咬肌功能减退对下颌生长及咀嚼肌协调性的影响：动物模型的体内研究
Odontology. 2025 Aug 12. doi: 10.1007/s10266-025-01171-9.
2
Botulinum toxin: a new differential diagnosis for a lytic bone lesion.肉毒杆菌毒素：溶骨性骨病变的新鉴别诊断。
J Med Case Rep. 2024 Mar 24;18(1):179. doi: 10.1186/s13256-024-04430-5.
3
Effect of the Correction of Bilateral Differences in Masseter Muscle Functional Pressure on the Mandible of Growing Rats.

本文引用的文献

1
The postoperative trismus, nerve injury and secondary angle formation after partial masseter muscle resection combined with mandibular angle reduction: a case report.部分咬肌切除联合下颌角缩小术后的牙关紧闭、神经损伤及继发角形成：1例报告
J Korean Assoc Oral Maxillofac Surg. 2017 Feb;43(1):46-48. doi: 10.5125/jkaoms.2017.43.1.46. Epub 2017 Feb 20.
2
Botulinum toxin related research in maxillofacial plastic and reconstructive surgery.肉毒杆菌毒素在颌面整形与重建外科的相关研究
Maxillofac Plast Reconstr Surg. 2016 Sep 5;38(1):34. doi: 10.1186/s40902-016-0080-2. eCollection 2016 Dec.
3
S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection.
咬肌功能压力双侧差异的纠正对生长中大鼠下颌骨的影响。
J Funct Biomater. 2023 Aug 21;14(8):435. doi: 10.3390/jfb14080435.
4
The perioral muscle continuum affects premaxillary development in Wistar rats.口周肌肉连续体影响Wistar大鼠的上颌前部发育。
Am J Transl Res. 2021 Nov 15;13(11):12364-12374. eCollection 2021.
5
Classification of the journal category "oral surgery" in the Scopus and the Science Citation Index Expanded: flaws and suggestions.Scopus和《科学引文索引扩展版》中“口腔外科”期刊类别的分类：缺陷与建议
J Korean Assoc Oral Maxillofac Surg. 2019 Aug;45(4):186-191. doi: 10.5125/jkaoms.2019.45.4.186. Epub 2019 Aug 28.
6
Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats.向发育中的大鼠二腹肌前腹注射A型肉毒杆菌毒素可增加上颌牙弓的后宽度。
Maxillofac Plast Reconstr Surg. 2019 May 6;41(1):20. doi: 10.1186/s40902-019-0203-7. eCollection 2019 Dec.
7
Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study.肉毒杆菌毒素A注射咀嚼肌致骨质减少大鼠中双膦酸盐对颞下颌关节的影响：一项初步研究
Maxillofac Plast Reconstr Surg. 2019 Mar 4;41(1):11. doi: 10.1186/s40902-019-0193-5. eCollection 2019 Dec.
8
Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings.肉毒毒素干预咀嚼肌后下颌骨骨丢失：从基础研究到临床发现的探讨。
Toxins (Basel). 2019 Feb 1;11(2):84. doi: 10.3390/toxins11020084.
9
The effect of botulinum toxin-A injection into the masseter muscles on prevention of plate fracture and post-operative relapse in patients receiving orthognathic surgery.肉毒杆菌毒素A注射咬肌对正颌手术患者预防钢板骨折及术后复发的影响。
Maxillofac Plast Reconstr Surg. 2018 Nov 25;40(1):36. doi: 10.1186/s40902-018-0174-0. eCollection 2018 Dec.
注射A型肉毒毒素后咬肌中S100和p65表达增加。
Maxillofac Plast Reconstr Surg. 2016 Aug 26;38(1):33. doi: 10.1186/s40902-016-0079-8. eCollection 2016 Dec.
4
Toxin yet not toxic: Botulinum toxin in dentistry.毒素却无毒：牙科中的肉毒杆菌毒素
Saudi Dent J. 2016 Apr;28(2):63-9. doi: 10.1016/j.sdentj.2015.08.002. Epub 2015 Dec 21.
5
Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers.肉毒杆菌毒素对大鼠咬肌的凋亡作用：分子标志物表达的早期和晚期变化
Springerplus. 2016 Jul 7;5(1):991. doi: 10.1186/s40064-016-2680-9. eCollection 2016.
6
A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment.A型肉毒杆菌毒素注射治疗颞下颌关节紊乱症的临床评估。
Maxillofac Plast Reconstr Surg. 2016 Jan 28;38(1):5. doi: 10.1186/s40902-016-0051-7. eCollection 2016 Dec.
7
Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation.肉毒杆菌毒素A注射大鼠咬肌的早期效应：功能与组织学评估
Maxillofac Plast Reconstr Surg. 2015 Dec 29;37(1):46. doi: 10.1186/s40902-015-0049-6. eCollection 2015 Dec.
8
Screening for variations in anterior digastric musculature prior to correction of post-traumatic anterior open bite by injection of botulinum toxin type A: a technical note.在通过注射A型肉毒杆菌毒素矫正创伤后前牙开合之前，对二腹肌前腹肌肉结构变化进行筛查：技术说明
J Korean Assoc Oral Maxillofac Surg. 2015 Jun;41(3):165-7. doi: 10.5125/jkaoms.2015.41.3.165. Epub 2015 Jun 23.
9
Effects of a botulinum toxin type A injection on the masseter muscle: An animal model study.A型肉毒杆菌毒素注射对咬肌的影响：一项动物模型研究。
Maxillofac Plast Reconstr Surg. 2015 Feb 24;37(1):10. doi: 10.1186/s40902-015-0010-8. eCollection 2015 Dec.
10
An Animal Model for Inducing Deviation of the Mandible.
J Oral Maxillofac Surg. 2015 Nov;73(11):2207-18. doi: 10.1016/j.joms.2015.03.051. Epub 2015 Mar 28.