Šujanská Anna, Ďurdík Peter, Rabasco Jole, Vitelli Ottavio, Pietropaoli Nicoletta, Villa Maria Pia
Department of Paediatrics, Jessenius Faculty of Medicine in Martin, Commenius University in Bratislava, Martin, Slovak Republic.
Neuroscience, Mental Health and Sense Organs Department, Pediatric Sleep Disease Centre, S. Andrea Hospital, "Sapienza" University of Rome, Rome, Italy.
Acta Medica (Hradec Kralove). 2014;57(4):135-41. doi: 10.14712/18059694.2015.78.
Interventions of paediatric obstructive sleep apnea syndrome are complex, varied and multidisciplinary. The goal of the treatment is to restore optimal breathing during the night and to relieve associated symptoms. Evidence suggests that the surgical intervention with removal of the tonsils and adenoids will lead to significant improvements in the most incomplicated cases, as recently reported from a meta-analysis. However, post-operative persistence of this syndrome in paediatric population is more frequent than expected, which supports the idea of the complexity of this syndrome. Adenotomy alone may not be sufficient in children with OSAS, because it does not address oropharyngeal obstruction secondary to tonsillar hyperplasia. Continuous positive airway pressure can effectively treat this syndrome in selected groups of children, improving both nocturnal and daytime symptoms, but poor adherence is a limiting factor. For this reason, CPAP is not recommended as first-line therapy for OSAS when adenotonsillectomy is an option. It is now being investigated the incorporation of nonsurgical approaches for milder forms and for residual OSAS after surgical intervention. Althought adeno-tonsillar hypertrophy is the most common for OSAS in children; obesity is emerging as an equally important etiological factor. Therefore an intensive weight reduction program and adequate sleep hygiene are also important lifestyle changes that may be very effective in mitigating the symptoms of this syndrome. Pharmacological therapy (leukotriene antagonists, topical nasal steroids) is usually use for mild forms of OSAS and in children with associated allergic diseases. Special orthodontic treatment and oropharyngeal exercises are a relatively new and promising alternative therapeutic modality used in selected groups of children with OSAS.
小儿阻塞性睡眠呼吸暂停综合征的干预措施复杂多样,涉及多学科。治疗的目标是恢复夜间的最佳呼吸状态并缓解相关症状。有证据表明,如最近一项荟萃分析所报道,在大多数不太复杂的病例中,切除扁桃体和腺样体的手术干预将带来显著改善。然而,该综合征在儿科人群中的术后持续情况比预期更常见,这支持了该综合征复杂性的观点。对于患有阻塞性睡眠呼吸暂停综合征的儿童,仅进行腺样体切除术可能并不足够,因为它无法解决扁桃体增生继发的口咽阻塞问题。持续气道正压通气可以有效治疗部分儿童群体的该综合征,改善夜间和白天的症状,但依从性差是一个限制因素。因此,当腺样体扁桃体切除术是一种选择时,不建议将持续气道正压通气作为阻塞性睡眠呼吸暂停综合征的一线治疗方法。目前正在研究将非手术方法用于较轻形式的病例以及手术干预后残留的阻塞性睡眠呼吸暂停综合征。虽然腺样体扁桃体肥大是儿童阻塞性睡眠呼吸暂停综合征最常见的病因,但肥胖正成为一个同样重要的病因因素。因此,强化减重计划和适当的睡眠卫生也是重要的生活方式改变,可能对减轻该综合征症状非常有效。药物治疗(白三烯拮抗剂、局部鼻用类固醇)通常用于轻度阻塞性睡眠呼吸暂停综合征病例以及伴有相关过敏性疾病的儿童。特殊的正畸治疗和口咽锻炼是用于部分阻塞性睡眠呼吸暂停综合征儿童群体的一种相对较新且有前景的替代治疗方式。