Sun Yutong, Ma Li
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Genes and Development Program, Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Trends Pharmacol Sci. 2015 Jun;36(6):349-59. doi: 10.1016/j.tips.2015.04.001. Epub 2015 May 1.
Metastasis is a 100-year-old research topic. Technological advances during the past few decades have led to significant progress in our understanding of metastatic disease. However, metastasis remains the leading cause of cancer-related mortalities. The lack of appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are major obstacles in metastasis prevention and treatment. Numerous processes, factors, and signaling pathways are involved in regulating metastasis. Here we discuss recent progress in metastasis research, including epithelial-mesenchymal plasticity, cancer stem cells, emerging molecular determinants and therapeutic targets, and the link between metastasis and therapy resistance.
转移是一个有着百年历史的研究课题。过去几十年间的技术进步使我们对转移性疾病的理解取得了重大进展。然而，转移仍然是癌症相关死亡的主要原因。缺乏针对转移预防药物的适当临床试验以及对分子机制的不完全理解是转移预防和治疗的主要障碍。众多过程、因素和信号通路参与调节转移。在此，我们讨论转移研究的最新进展，包括上皮-间质可塑性、癌症干细胞、新出现的分子决定因素和治疗靶点，以及转移与治疗耐药性之间的联系。
