螺硼酸硅罗丹明作为一种基于可逆开环过程的近红外溶酶体成像探针。
Spiroboronate Si-rhodamine as a near-infrared probe for imaging lysosomes based on the reversible ring-opening process.
作者信息
Zhu Weiwei, Chai Xiaoyun, Wang Baogang, Zou Yan, Wang Ting, Meng Qingguo, Wu Qiuye
机构信息
College of Pharmacy, Yantai University, Yantai, Shandong 264005, China.
出版信息
Chem Commun (Camb). 2015 Jun 14;51(47):9608-11. doi: 10.1039/c5cc02496j.
PMID:25939985
Abstract
A cyclic boronate structure was incorporated into Si-rhodamine to design a pH-activatable near-infrared (NIR) probe based on the reversible ring-opening process triggered by H(+). The probe showed general suitability of specific labelling of acidic lysosomes and tracking their pH changes in living cells.
摘要
将环状硼酸酯结构引入硅罗丹明中，基于氢离子引发的可逆开环过程设计了一种pH可激活的近红外（NIR）探针。该探针显示出对酸性溶酶体进行特异性标记并追踪其在活细胞中pH变化的普遍适用性。
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