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采用全基因组测序技术对丹麦血液感染患者的一株多药耐药脆弱拟杆菌分离株进行特征分析。

Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing.

机构信息

Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Brendstrupgårdsvej 100, DK-8200 Aarhus N, Denmark.

Department of Clinical Microbiology, Odense University Hospital, J.B. Winsløws vej 21.2, DK-5000 Odense C, Denmark.

出版信息

Int J Antimicrob Agents. 2015 Jul;46(1):117-20. doi: 10.1016/j.ijantimicag.2015.02.024. Epub 2015 Apr 17.

DOI:10.1016/j.ijantimicag.2015.02.024
PMID:25940770
Abstract

Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.

摘要

在这里，我们描述了一位因乙状结肠癌伴腹膜癌病而行广泛腹部手术和腹腔内热灌注化疗的患者。住院期间，该患者发生了多重耐药脆弱拟杆菌引起的菌血症。对分离株进行全基因组测序，结果发现了与甲硝唑、碳青霉烯类和克林霉素耐药相关的 nimE、cfiA 和 ermF 基因。

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