Cardiff-China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff, UK.
Breast Cancer (Dove Med Press). 2015 Apr 24;7:99-109. doi: 10.2147/BCTT.S59006. eCollection 2015.
The Wiskott-Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton. The role of WASP/WAVE family proteins in the control of actin polymerization through activation of the actin-related protein 2/3 complex is critical in the formation of the actin-based membrane protrusions seen in cell migration and invasion. For this reason, the activity of the WASP/WAVE family in cancer cell invasion and migration has been of great interest in recent years. Many reports have highlighted the potential of targeting the WASP/WAVE family as a therapy for the prevention of cancer progression, in particular breast cancer. This review focuses on the role of the WASP/WAVE family in breast cancer cell invasion and migration and how this relates to the molecular mechanisms of WASP/WAVE activity, their exact contributions to the stages of cancer progression, and how this can lead to the development of anticancer drugs that target the WASP/WAVE family and related pathways.
Wiskott-Aldrich 综合征蛋白（WASP）和 WASP 家族 verprolin 同源蛋白（WAVE）家族是一组分子，它们在 GTP 酶和肌动蛋白细胞骨架之间形成关键连接。WASP/WAVE 家族蛋白在通过激活肌动蛋白相关蛋白 2/3 复合物来控制肌动蛋白聚合中的作用对于细胞迁移和侵袭中观察到的基于肌动蛋白的膜突起的形成至关重要。因此，近年来，WASP/WAVE 家族在癌细胞侵袭和迁移中的活性引起了极大的关注。许多报告强调了靶向 WASP/WAVE 家族作为预防癌症进展的治疗方法的潜力，特别是乳腺癌。这篇综述重点介绍了 WASP/WAVE 家族在乳腺癌细胞侵袭和迁移中的作用，以及这与 WASP/WAVE 活性的分子机制、它们对癌症进展阶段的确切贡献以及如何导致开发针对 WASP/WAVE 家族和相关途径的抗癌药物有关。
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