de Figueiredo Sonia M, Binda Nancy S, Nogueira-Machado Jose A, Vieira-Filho Sidney A, Caligiorne Rachel B
Escola de Nutricao, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto Minas Gerais, CEP 35400-000, Brazil.
Recent Pat Endocr Metab Immune Drug Discov. 2015;9(1):24-39. doi: 10.2174/1872214809666150505164138.
Sulforaphane (SFN) is a molecule within the isothiocyanate (ITC) group of organosulfur compounds. SFN is a phytochemical commonly found in cruciferous vegetables such as broccoli, brussels sprouts and cabbages. It has been widely studied in order to evaluate its chemopreventive properties and some of those have already been established by means of animal and human models. The SFN induces Phase I and II enzymes involved in detoxification processes of chemical carcinogens in order to prevent the start of carcinogenesis. It also presents anti-tumor action at post-initiation Phase, suggesting supplementary roles in cancer prevention. In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present antiinflammatory effect acting during the initial of uncontrolled cell proliferation. This protective effect may be due to its antioxidant status, its recognized capacity to induce the expression and/or activity of of different cytoprotective proteins involved in the activating "Nuclear factor erythroid-derived 2-like 2" (Nrf2). Nevertheless, the effects on health and the possible connections among different diet constituents in humans must be carefully studied as there are limitations in the current data in order to better understand the molecular mechanisms responsible for those effects. This survey also includes relevant patents on the use of SFN, like its use in skin cancer treatment (US2015038580); and as an adjuvant in anti-cancer treatment (US2014228419). The use of SFN as an antioxidant dietary supplement, methods for compositions that promote glutathione production (WO2015002279) and methods for extracting and purifying SFN from broccoli seeds (CN104086469) are also included in this review.
萝卜硫素（SFN）是有机硫化合物异硫氰酸盐（ITC）组中的一种分子。SFN是一种植物化学物质，常见于十字花科蔬菜中，如西兰花、抱子甘蓝和卷心菜。为了评估其化学预防特性，人们对其进行了广泛研究，其中一些特性已通过动物和人体模型得到证实。SFN诱导参与化学致癌物解毒过程的I相和II相酶，以预防致癌作用的开始。它在启动后阶段也具有抗肿瘤作用，表明在癌症预防中具有辅助作用。ITC以剂量依赖的方式抑制人类癌细胞的活力，改变癌细胞中发生的表观遗传事件，并在不受控制的细胞增殖初期发挥抗炎作用。这种保护作用可能归因于其抗氧化状态，以及其公认的诱导参与激活“核因子红细胞衍生2样2”（Nrf2）的不同细胞保护蛋白表达和/或活性的能力。然而，由于目前的数据存在局限性，必须仔细研究其对健康的影响以及人类不同饮食成分之间可能的联系，以便更好地理解导致这些影响的分子机制。本综述还包括有关SFN用途的相关专利，如用于皮肤癌治疗（美国专利2015038580）；以及作为抗癌治疗的佐剂（美国专利2014228419）。本综述还包括将SFN用作抗氧化膳食补充剂、促进谷胱甘肽产生的组合物的方法（国际专利申请WO2015002279）以及从西兰花种子中提取和纯化SFN的方法（中国专利CN104086469）。
