[Glycolysis activation, a decrease in the glycogen reserve and the absence of glucocorticoid control over the enzymes of carbohydrate metabolism in the liver of rats under prolonged hypokinetic stress].

The content of 11-oxycorticosteroids in blood plasma, the content of glycogen in the liver and the correlation of processes of glycolysis and gluconeogenesis in it (according to the activity of the key enzymes) were studied in rats in the course of chronic stress (on day 5, 15, 30, 45, and 60) induced by keeping the animals under conditions of severe hypokinesia. The 11-oxycorticosteroic content increased on the 5th, 45th, and 60th day of stress. On the 5th day processes of gluconeogenesis in the liver prevailed over processes of glycolysis, on the 60th day glycolysis prevailed over gluconeogenesis. On the 45th-60th days the content of glycogen in the liver reduces and the activity of the key enzymes becomes exempt from hormonal control.