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阿尔茨海默病患者的氧化应激：发酵木瓜粉提取物的作用

Oxidative stress in patients with Alzheimer's disease: effect of extracts of fermented papaya powder.

作者信息

Barbagallo Mario, Marotta Francesco, Dominguez Ligia J

机构信息

Geriatric Unit, Department DIBIMIS, University of Palermo, Via del Vespro, 129, 90127 Palermo, Italy ; UOC di Geriatria e Lungodegenza, AOUP Azienda Universitaria Policlinico, Via del Vespro, 129, 90127 Palermo, Italy.

ReGenera Research Group for Aging Intervention, Milano, Italy.

出版信息

Mediators Inflamm. 2015;2015:624801. doi: 10.1155/2015/624801. Epub 2015 Apr 7.

DOI:10.1155/2015/624801
PMID:25944987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4405021/
Abstract

Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer's disease (AD). Postmortem studies in AD patients' brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product of Carica papaya Linn fermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 controls. Urinary 8-OHdG was measured to assess OS. Twenty AD patients were supplemented with FPP (Immunage, 4.5 grams/day) for 6 months, while controls did not receive any treatment. At baseline, 8-OHdG was significantly higher in patients with AD versus controls (13.7 ± 1.61 ng/mL versus 1.6 ± 0.12 ng/mL, P < 0.01). In AD patients FPP significantly decreased 8-OHdG (14.1 ± 1.7 ng/mL to 8.45 ± 1.1 ng/mL, P < 0.01), with no significant changes in controls. AD is associated with increased OS, and FPP may be helpful to counteract excessive ROS in AD patients.

摘要

脑组织对氧化应激（OS）特别敏感。活性氧（ROS）生成增加、抗氧化系统功能降低以及修复机制效率下降都与阿尔茨海默病（AD）有关。对AD患者大脑的尸检研究已显示出氧化损伤标志物（即脂质过氧化、蛋白质氧化损伤和糖基化氧化）。发酵木瓜（FPP，番木瓜与酵母发酵的产物）是一种营养补充剂，对慢性/退行性疾病的免疫、血液、炎症和OS参数具有有益作用。我们研究了40名患者（年龄78.2±1.1岁），其中28名AD患者和12名对照。通过测量尿8-羟基脱氧鸟苷来评估OS。20名AD患者补充FPP（免疫宝，4.5克/天），为期6个月，而对照组未接受任何治疗。基线时，AD患者的8-羟基脱氧鸟苷显著高于对照组（13.7±1.61纳克/毫升对1.6±0.12纳克/毫升，P<0.01）。在AD患者中，FPP显著降低了8-羟基脱氧鸟苷（从14.1±1.7纳克/毫升降至8.45±1.1纳克/毫升，P<0.01），而对照组无显著变化。AD与OS增加有关，FPP可能有助于抵消AD患者体内过多的ROS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/4ec55b7c935d/MI2015-624801.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/9939afe372f2/MI2015-624801.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/40eaf543c2b4/MI2015-624801.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/4ec55b7c935d/MI2015-624801.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/9939afe372f2/MI2015-624801.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/40eaf543c2b4/MI2015-624801.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e86/4405021/4ec55b7c935d/MI2015-624801.003.jpg

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