肉毒杆菌毒素治疗对痉挛的影响。
Effect of treatment with botulinum toxin on spasticity.
作者信息
Das T K, Park D M
机构信息
Southend District Stroke Unit, Rochford Hospital, Essex, UK.
出版信息
Postgrad Med J. 1989 Apr;65(762):208-10. doi: 10.1136/pgmj.65.762.208.
Abstract
Botulinum toxin, a product of Clostridium botulinum, produces presynaptic neuromuscular block by preventing release of acetylcholine from nerve endings. The toxin was injected directly into the skeletal muscles of six patients with severe spasticity due to stroke-related hemiplegia. It produced both subjective and objective improvement. The toxin injections were well tolerated and no significant side effect was reported.
摘要
肉毒杆菌毒素是肉毒梭菌产生的一种产物，它通过阻止乙酰胆碱从神经末梢释放来产生突触前神经肌肉阻滞。将该毒素直接注射到6名因中风相关性偏瘫而患有严重痉挛的患者的骨骼肌中。它产生了主观和客观的改善。毒素注射耐受性良好，未报告有明显副作用。
相似文献
1
Effect of treatment with botulinum toxin on spasticity.肉毒杆菌毒素治疗对痉挛的影响。
Postgrad Med J. 1989 Apr;65(762):208-10. doi: 10.1136/pgmj.65.762.208.
2
Botulinum toxin in treating spasticity.肉毒杆菌毒素治疗痉挛
Br J Clin Pract. 1989 Nov;43(11):401-3.
3
Botulinum toxin treatment for lower limb extensor spasticity in chronic hemiparetic patients.肉毒杆菌毒素治疗慢性偏瘫患者下肢伸肌痉挛
J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1321-4. doi: 10.1136/jnnp.57.11.1321.
4
[Treatment of spasticity with botulinum toxin].[肉毒杆菌毒素治疗痉挛]
Rev Neurol (Paris). 1992;148(3):212-4.
5
Spasticity associated with cerebral palsy in children: guidelines for the use of botulinum A toxin.儿童脑瘫相关的痉挛状态：A型肉毒毒素使用指南
Paediatr Drugs. 2003;5(1):11-23. doi: 10.2165/00128072-200305010-00002.
6
[Molecular mechanism of botlinum toxin therapy for spasticity].[肉毒杆菌毒素治疗痉挛的分子机制]
Rinsho Shinkeigaku. 2012;52(11):1270-1. doi: 10.5692/clinicalneurol.52.1270.
7
Injectable neuromuscular blockade in the treatment of spasticity and movement disorders.注射用神经肌肉阻滞在痉挛和运动障碍治疗中的应用
J Child Neurol. 2003 Sep;18 Suppl 1:S50-66. doi: 10.1177/0883073803018001S0701.
8
Botulinum toxin for the treatment of spasticity in multiple sclerosis. New observations.肉毒杆菌毒素治疗多发性硬化症的痉挛状态。新观察结果。
Am J Phys Med Rehabil. 1993 Dec;72(6):364-8.
9
Use of botulinum toxin in stroke patients with severe upper limb spasticity.肉毒杆菌毒素在重度上肢痉挛性脑卒中患者中的应用。
J Neurol Neurosurg Psychiatry. 1996 Jul;61(1):30-5. doi: 10.1136/jnnp.61.1.30.
10
Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after stroke.肌肉注射肉毒杆菌毒素治疗中风后手腕和手指痉挛。
Med J Malaysia. 2007 Oct;62(4):319-22.
引用本文的文献
1
The Impact of Repeated Applications of Botulinum Toxin A on the Spasticity of the Upper Limb in Stroke Patient, Cohort Study.肉毒杆菌毒素A重复应用对中风患者上肢痉挛的影响：队列研究
J Clin Med. 2025 Apr 16;14(8):2735. doi: 10.3390/jcm14082735.
2
The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis.A型肉毒毒素在痉挛中的作用：基于文献计量分析的研究趋势。
Toxins (Basel). 2024 Apr 9;16(4):184. doi: 10.3390/toxins16040184.
3
High Doses of Botulinum Toxin Type A for the Treatment of Post-Stroke Spasticity: Rationale for a Real Benefit for the Patients.A型肉毒毒素大剂量治疗脑卒中后痉挛：对患者有益的基本原理。
Toxins (Basel). 2022 May 6;14(5):332. doi: 10.3390/toxins14050332.
4
TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.TAMM41 通过调节 PINK-PARK2 依赖性线粒体自噬对于心脏瓣膜分化是必需的。
Cell Death Differ. 2019 Nov;26(11):2430-2446. doi: 10.1038/s41418-019-0311-z. Epub 2019 Mar 1.
5
Botulinum Toxin Type A for the Treatment of Lower Limb Spasticity after Stroke.A型肉毒毒素治疗脑卒中后下肢痉挛。
Drugs. 2019 Feb;79(2):143-160. doi: 10.1007/s40265-018-1042-z.
6
Renal Sympathetic Denervation - A Review of Applications in Current Practice.肾交感神经去神经支配——当前实践中的应用综述
Interv Cardiol. 2014 Mar;9(1):54-61. doi: 10.15420/icr.2011.9.1.54.
7
Benefits and Risks of Non-Approved Injection Regimens for Botulinum Toxins in Spasticity.肉毒毒素治疗痉挛的未批准注射方案的获益与风险。
Drugs. 2017 Sep;77(13):1413-1422. doi: 10.1007/s40265-017-0786-1.
8
Clinical study of botulinum toxin A injection combined with spasmodic muscle therapeutic instrument on lower limb spasticity in patients with stroke.A型肉毒毒素注射联合痉挛肌治疗仪治疗脑卒中患者下肢痉挛的临床研究
Exp Ther Med. 2017 Jun;13(6):3319-3326. doi: 10.3892/etm.2017.4376. Epub 2017 Apr 24.
9
Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle.评估肉毒杆菌毒素注射对痉挛肌肉阻抗的即时影响。
Med Eng Phys. 2017 May;43:97-102. doi: 10.1016/j.medengphy.2017.01.018. Epub 2017 Feb 4.
10
Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity.incobotulinumtoxinA作为中风后痉挛潜在治疗方法的安全性和有效性。
Neuropsychiatr Dis Treat. 2016 Jan 27;12:251-63. doi: 10.2147/NDT.S86978. eCollection 2016.
本文引用的文献
1
FUNCTIONAL EVALUATION: THE BARTHEL INDEX.功能评估：巴氏指数
Md State Med J. 1965 Feb;14:61-5.
2
Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery.眼外肌注射肉毒杆菌毒素作为斜视手术的替代方法。
Ophthalmology. 1980 Oct;87(10):1044-9. doi: 10.1016/s0161-6420(80)35127-0.
3
Editorial: Spasticity: the fable of a neurological demon and the emperor's new therapy.社论：痉挛：一个神经学恶魔的传说与皇帝的新疗法
Arch Neurol. 1974 Oct;31(4):217-9. doi: 10.1001/archneur.1974.00490400031001.
4
Effect of treatment with botulinum toxin on neurogenic blepharospasm.肉毒杆菌毒素治疗对神经源性睑痉挛的影响。
Br Med J (Clin Res Ed). 1985 Jun 22;290(6485):1857-9. doi: 10.1136/bmj.290.6485.1857.
5
Long-term results of treatment of idiopathic blepharospasm with botulinum toxin injections.肉毒杆菌毒素注射治疗特发性眼睑痉挛的长期效果
Br J Ophthalmol. 1987 Sep;71(9):664-8. doi: 10.1136/bjo.71.9.664.
6
7
Double-blind study of botulinum toxin in spasmodic torticollis.肉毒杆菌毒素治疗痉挛性斜颈的双盲研究。
Lancet. 1986 Aug 2;2(8501):245-7. doi: 10.1016/s0140-6736(86)92070-2.
8
Grading of spasticity and its effect on voluntary movement.痉挛的分级及其对随意运动的影响。
Physiotherapy. 1976 Nov;62(11):358-61.
9
Botulinum toxin: mechanism of presynaptic blockade.
Science. 1976 Sep 24;193(4259):1256-8. doi: 10.1126/science.785600.
10
Stroke rehabilitation: analysis of repeated Barthel index measures.中风康复：重复巴氏指数测量分析
Arch Phys Med Rehabil. 1979 Jan;60(1):14-7.
Zotero 插件