Das T K, Park D M
Southend District Stroke Unit, Rochford Hospital, Essex, UK.
Postgrad Med J. 1989 Apr;65(762):208-10. doi: 10.1136/pgmj.65.762.208.
Botulinum toxin, a product of Clostridium botulinum, produces presynaptic neuromuscular block by preventing release of acetylcholine from nerve endings. The toxin was injected directly into the skeletal muscles of six patients with severe spasticity due to stroke-related hemiplegia. It produced both subjective and objective improvement. The toxin injections were well tolerated and no significant side effect was reported.
肉毒杆菌毒素是肉毒梭菌产生的一种产物，它通过阻止乙酰胆碱从神经末梢释放来产生突触前神经肌肉阻滞。将该毒素直接注射到6名因中风相关性偏瘫而患有严重痉挛的患者的骨骼肌中。它产生了主观和客观的改善。毒素注射耐受性良好，未报告有明显副作用。
