Neubert Franz-Xaver, Mars Rogier B, Sallet Jérôme, Rushworth Matthew F S
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, The Netherlands.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2695-704. doi: 10.1073/pnas.1410767112. Epub 2015 May 6.
Reward-guided decision-making depends on a network of brain regions. Among these are the orbitofrontal and the anterior cingulate cortex. However, it is difficult to ascertain if these areas constitute anatomical and functional unities, and how these areas correspond between monkeys and humans. To address these questions we looked at connectivity profiles of these areas using resting-state functional MRI in 38 humans and 25 macaque monkeys. We sought brain regions in the macaque that resembled 10 human areas identified with decision making and brain regions in the human that resembled six macaque areas identified with decision making. We also used diffusion-weighted MRI to delineate key human orbital and medial frontal brain regions. We identified 21 different regions, many of which could be linked to particular aspects of reward-guided learning, valuation, and decision making, and in many cases we identified areas in the macaque with similar coupling profiles.
奖励引导的决策依赖于一个脑区网络。其中包括眶额皮质和前扣带回皮质。然而，很难确定这些区域是否构成解剖学和功能上的统一体，以及这些区域在猴子和人类之间是如何对应的。为了解决这些问题，我们使用静息态功能磁共振成像观察了38名人类和25只猕猴中这些区域的连接图谱。我们在猕猴中寻找类似于10个通过决策确定的人类区域的脑区，以及在人类中寻找类似于6个通过决策确定的猕猴区域的脑区。我们还使用扩散加权磁共振成像来描绘关键的人类眶部和内侧额叶脑区。我们识别出21个不同的区域，其中许多区域可能与奖励引导学习、评估和决策的特定方面相关联，并且在许多情况下，我们在猕猴中识别出具有相似耦合图谱的区域。
