Sarker Anita, Meek Claire L, Park Adrian
Department of Clinical Biochemistry and Immunology, Cambridge Universities NHS foundation trust, Addenbrooke's Hospital, Cambridge, UK.
Department of Clinical Biochemistry and Immunology, Cambridge Universities NHS foundation trust, Addenbrooke's Hospital, Cambridge, UK Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Ann Clin Biochem. 2016 Jan;53(Pt 1):21-31. doi: 10.1177/0004563215588116. Epub 2015 May 6.
Obesity, defined as a body mass index over 30 kg/m(2) for adults, poses a major healthcare challenge with important economic, personal and social consequences. Although public health measures, lifestyle change and pharmacological therapies have an important role in the management of obesity, patients with established morbid obesity (body mass index over 40 kg/m(2)) may also require bariatric surgery. Bariatric or metabolic surgery is associated with effective and enduring weight loss but is also known to improve glucose homeostasis, blood pressure and dyslipidaemia. Patients who have bariatric surgery need lifelong clinical follow-up to identify and prevent nutritional deficiencies and other complications. Clinical biochemistry laboratories have an important role in the nutritional assessment of obese patients and in the identification of complications following bariatric surgery. The aim of this article is to review the different bariatric procedures available and to summarize their complications, especially nutrient deficiencies and those of particular relevance to clinical biochemistry laboratories.
肥胖定义为成人体重指数超过30kg/m²，这对医疗保健构成了重大挑战，会产生重要的经济、个人和社会后果。尽管公共卫生措施、生活方式改变和药物治疗在肥胖管理中发挥着重要作用，但确诊为病态肥胖（体重指数超过40kg/m²）的患者可能还需要进行减肥手术。减肥或代谢手术与有效且持久的体重减轻相关，而且还已知其能改善葡萄糖稳态、血压和血脂异常。接受减肥手术的患者需要终身临床随访，以识别和预防营养缺乏及其他并发症。临床生物化学实验室在肥胖患者的营养评估以及减肥手术后并发症的识别方面发挥着重要作用。本文旨在综述现有的不同减肥手术程序，并总结其并发症，尤其是营养缺乏以及与临床生物化学实验室特别相关的并发症。
