印度帕金森病患者队列中的非运动症状以及非运动症状进展与运动功能恶化的相关性。
Non-motor symptoms in an Indian cohort of Parkinson's disease patients and correlation of progression of non-motor symptoms with motor worsening.
作者信息
Ravan Amruta, Ahmad Faiz M H, Chabria Sonali, Gadhari Mangesh, Sankhla Charulata Savant
机构信息
Department of Neurology, P D Hinduja National Hospital, Mumbai, Maharashtra, India.
出版信息
Neurol India. 2015 Mar-Apr;63(2):166-74. doi: 10.4103/0028-3886.156276.
AIM
To document the frequency and prevalence of non-motor symptoms (NMS) in an Indian cohort of Parkinson's disease (PD) patients.
OBJECTIVES
To validate the non-motor score scale (NMSS) in an Indian cohort of PD patients for recording NMS of the disease, to study the prevalence and frequency of NMS in Indian PD patients using the NMSS, and to compare the progression of NMS with motor worsening. Conclusion and Results: This was a cross-sectional, single-center, open-label, one point in time evaluation study conducted from 2009 to 2011. It validated the NMSS scale in an Indian population. The study has profiled the prevalence and pattern of NMS in an Indian cohort of PD patients. Comparison of NMS scale scores with the Unified PD Rating Scale motor scores demonstrated a correlation between non-motor and motor symptoms in the disease progression, particularly of manifestations related to the cognitive decline, memory disturbances, urinary incontinence and smell.
目的
记录印度帕金森病（PD）患者队列中非运动症状（NMS）的发生频率和患病率。
目标
在印度PD患者队列中验证非运动评分量表（NMSS）以记录该疾病的NMS，使用NMSS研究印度PD患者中NMS的患病率和发生频率，并比较NMS进展与运动功能恶化情况。结论与结果：这是一项于2009年至2011年进行的横断面、单中心、开放标签、时间点评估研究。它在印度人群中验证了NMSS量表。该研究描绘了印度PD患者队列中NMS的患病率和模式。将NMS量表评分与统一PD评定量表运动评分进行比较，结果表明在疾病进展过程中，非运动症状与运动症状之间存在相关性，尤其是与认知衰退、记忆障碍、尿失禁和嗅觉相关的表现。
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