Klinger W, Hirschelmann R, Süss J
Institute of Pharmacology and Toxicology, Friedrich-Schiller-University Jena, GDR.
Pharmazie. 1989 Aug;44(8):558-60.
Birch sap and birch leaves extract have been screened for antimicrobial, phagocytosis-influencing, anti-inflammatory and antipyretic activity. No antimicrobial effects could be detected in the agar-diffusion test with staphylococcus as test strain, whereas birch sap exhibited some inhibitory effect on phagocytosis, which exceeded that of the citric acid added to the birch sap as preservative. In rats, only the high doses of 1 and 2 ml/100 g b.m. birch sap had a weak and short-lasting anti-inflammatory activity against the Carrageenin edema, whereas birch leaves extract proved to be ineffective. Fever induced by baker's yeast in rats was inhibited by birch leaves extract in the high dose of 4 ml/100 g b.m. significantly, but not by birch sap, and only for a short period. Acetylsalicyclic acid had a much higher anti-inflammatory and antipyretic activity. Altogether despite of detectable anti-inflammatory, antipyretic and phagocytosis-inhibiting effects of these birch products no therapeutic activity of importance compared with classical and modern antipyretics-analgetics can be demonstrated.
已对白桦树液和桦树叶提取物进行了抗菌、影响吞噬作用、抗炎和解热活性的筛选。以葡萄球菌为测试菌株进行琼脂扩散试验时，未检测到抗菌作用，而桦树液对吞噬作用表现出一定的抑制作用，这种抑制作用超过了作为防腐剂添加到桦树液中的柠檬酸。在大鼠中，仅高剂量（1和2毫升/100克体重）的桦树液对角叉菜胶性水肿具有微弱且持续时间短的抗炎活性，而桦树叶提取物则无效。高剂量（4毫升/100克体重）的桦树叶提取物可显著抑制大鼠由面包酵母诱导的发热，但桦树液无此作用，且仅在短时间内有效。乙酰水杨酸具有更高的抗炎和解热活性。总之，尽管这些桦树产品具有可检测到的抗炎、解热和抑制吞噬作用，但与经典和现代的解热镇痛药相比，未显示出重要的治疗活性。
