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下颌前部区域透明细胞牙源性癌的一种不寻常表现。

An unusual presentation of clear cell odontogenic carcinoma in mandibular anterior region.

作者信息

Ganvir Sindhu M, Gajbhiye Namrata Yashwant

机构信息

Department of Oral Pathology, Government Dental College and Hospital Nagpur, Maharashtra, India.

出版信息

J Oral Maxillofac Pathol. 2014 Sep-Dec;18(3):442-8. doi: 10.4103/0973-029X.151344.

DOI:10.4103/0973-029X.151344
PMID:25949004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4409194/
Abstract

Clear cell odontogenic carcinoma (CCOC) is a rare, potentially aggressive odontogenic epithelial tumor with tendency for recurrence. It was first described as a clinicopathological entity in 1985 and to date only 73 cases has been reported in English literature. A case of CCOC in 64-year-old male patient in mandibular anterior region is presented which when recurred in soft tissue 5 years after wide surgical resection of mandible, revealed a biphasic pattern as against monophasic pattern of primary neoplasm and was unusually associated with primary squamous cell carcinoma, suggestive of hybrid tumor.

摘要

透明细胞牙源性癌(CCOC)是一种罕见的、具有潜在侵袭性的牙源性上皮肿瘤,有复发倾向。它于1985年首次被描述为一种临床病理实体,迄今为止,英文文献中仅报道了73例。本文报告了1例64岁男性患者下颌前部区域的CCOC病例,该患者在接受下颌骨广泛手术切除5年后软组织复发,显示出双相模式,与原发性肿瘤的单相模式不同,且异常地与原发性鳞状细胞癌相关,提示为混合性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/3eb9075cccf5/JOMFP-18-442-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/95634af3fd3d/JOMFP-18-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/f8a332963fd1/JOMFP-18-442-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/2a98eca6fa66/JOMFP-18-442-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/35707d784ca7/JOMFP-18-442-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/933fb4516915/JOMFP-18-442-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/08b7e498b1ef/JOMFP-18-442-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/e17fec663ca1/JOMFP-18-442-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/3eb9075cccf5/JOMFP-18-442-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/95634af3fd3d/JOMFP-18-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/f8a332963fd1/JOMFP-18-442-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/2a98eca6fa66/JOMFP-18-442-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/35707d784ca7/JOMFP-18-442-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/933fb4516915/JOMFP-18-442-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/08b7e498b1ef/JOMFP-18-442-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/e17fec663ca1/JOMFP-18-442-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd2/4409194/3eb9075cccf5/JOMFP-18-442-g008.jpg

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本文引用的文献

1
Clear cell odontogenic carcinoma of maxilla: A case report and mini review.上颌骨透明细胞牙源性癌:一例报告及简要综述
J Oral Maxillofac Pathol. 2013 Jan;17(1):89-94. doi: 10.4103/0973-029X.110681.
2
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.头颈部癌患者第二原发性肿瘤/复发的新型易感基因座:基因变异的大规模评估
Cancer Prev Res (Phila). 2009 Jul;2(7):617-24. doi: 10.1158/1940-6207.CAPR-09-0025.
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Clear cell odontogenic carcinoma: a diagnostic and therapeutic dilemma.
透明细胞牙源性癌:一种罕见的颌骨肿瘤。107 例报告病例总结。
Int J Oral Maxillofac Surg. 2019 Nov;48(11):1405-1410. doi: 10.1016/j.ijom.2019.05.006. Epub 2019 Jun 18.
透明细胞牙源性癌:诊断与治疗的困境
World J Surg Oncol. 2006 Dec 12;4:91. doi: 10.1186/1477-7819-4-91.
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Clear cell odontogenic carcinoma: a comprehensive analysis of treatment strategies.透明细胞牙源性癌:治疗策略的综合分析
Head Neck. 2005 Jun;27(6):536-42. doi: 10.1002/hed.20181.
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Distinguishing de novo second cancer formation from tumor recurrence: mutational fingerprinting by microdissection genotyping.区分新发第二癌症形成与肿瘤复发:通过显微切割基因分型进行突变指纹分析。
J Mol Diagn. 2001 Nov;3(4):129-32. doi: 10.1016/S1525-1578(10)60663-0.
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Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.是第二原发性肿瘤还是复发性肿瘤?p53和K-ras突变的比较模式表明,浆液性交界性卵巢肿瘤及随后发生的浆液性癌是不相关的肿瘤。
Cancer Res. 2001 Oct 1;61(19):7264-7.