Angali Rama Krishna, Jeshtadi Anunayi, Namala Vivek Anand, Gannepalli Ashalata
Department of Oral Pathology and Microbiology, Panineeya Institute of Dental Sciences and Research Center, Kamala Nagar, Dilsukhnagar, Hyderabad, India.
Department of Pathology, Osmania Medical College, Koti, Hyderabad, Andhra Pradesh, India.
J Oral Maxillofac Pathol. 2014 Sep-Dec;18(3):460-3. doi: 10.4103/0973-029X.151355.
Rhino-orbital-cerebral zygomycosis is a potentially lethal, opportunistic, fungal infection with protean manifestations, rapid progression, unpredictable course and high mortality. It is associated with angioinvasion and infarction, usually observed in diabetic ketoacidosis, immuno-compromised states and rarely reported in an apparently normal host. We present a case of an18-year-old patient with a chronic, painful, non healing ulcer with necrotic margins over the right side of the face which extended to both orbits involving eyes within a period of 1.5 month. Later he developed severe headache, decreased vision, inability to speak, seizures and status epilepticus with fatal outcome. Awareness of its occurrence in normal patients with prompt diagnosis and appropriate management may improve the outcome and decrease mortality.
鼻眶脑型毛霉菌病是一种具有潜在致命性的机会性真菌感染，表现形式多样，进展迅速，病程难以预测，死亡率高。它与血管侵袭和梗死相关，常见于糖尿病酮症酸中毒、免疫功能低下状态，在看似正常的宿主中很少见。我们报告一例18岁患者，面部右侧有一个慢性、疼痛、不愈合的溃疡，边缘坏死，1.5个月内扩展至双侧眼眶并累及双眼。后来他出现严重头痛、视力下降、失语、癫痫发作和癫痫持续状态，最终死亡。认识到其在正常患者中的发生，及时诊断并进行适当治疗，可能改善预后并降低死亡率。
