†Universidad de Santiago de Compostela, Departamento de Farmacología, Facultad de Veterinaria, 27002 Lugo, Spain.
‡Université Paris Descartes, Laboratoire de Pharmacognosie et de Chimie des Substances Naturelles, COMETE UMR 8638 CNRS, 4 Avenue de l'Observatoire, 75006 Paris, France.
Org Lett. 2015 May 15;17(10):2392-5. doi: 10.1021/acs.orglett.5b00902. Epub 2015 May 7.
A new natural product named gambierone (1) was isolated from the cultured dinoflagellate Gambierdiscus belizeanus. The structure of this compound features an unprecedented polyether skeleton and an unusual right-hand side chain. Its relative configuration was fully determined by interpretation of ROESY experiment and comparison between experimental and theoretical NMR data. Although the succession of cycles has no chemical similarity with ciguatoxins, 1 has a molecular formula and biological activity similar to those of CTX-3C, although much lower in intensity.
一种新的天然产物 Gambierone（1）从培养的甲藻 Gambierdiscus belizeanus 中分离得到。该化合物的结构具有前所未有的聚醚骨架和不寻常的右手侧链。通过 ROESY 实验的解释和实验与理论 NMR 数据的比较，确定了其相对构型。尽管环的顺序与雪卡毒素没有化学相似性，但 1 的分子式和生物活性与 CTX-3C 相似，尽管强度要低得多。
