Shen Jian Guo, Jin Li Dan, Dong Min Jun, Wang Lin Bo, Zhao Wen He, Shen Jun
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University College of medicine, Hangzhou, China.
Transl Cancer Res. 2020 Oct;9(10):6206-6213. doi: 10.21037/tcr-20-1220.
The clinical significance of lipid profile in gastric cancer remains unclear. The aim of the present study was to investigate the correlation between serum lipid profiles and patient clinical parameters as well as prognosis in gastric cancer.
The preoperative plasma lipid profile levels of 358 gastric cancer patients, who were operated in between 2001 and 2009, were retrospectively evaluated, and the correlation between these factors and patient clinical parameters as well as survival were analyzed.
There was a significant association between serum high-density lipoprotein cholesterol level (HDL-C <54.2 mg/dL) and cancer progression, Logistic regression analysis revealed that lower level of serum HDL-C was an independent risk factor for deeper cancer invasion, nodal metastasis as well as late stage in patients with gastric cancer. However, no significant association was reported between other lipid markers [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL) and apolipoprotein A (apoA)] and lymph node involvement as well as stage of disease. In univariate analysis and multivariate analyses regarding patient's survival, there was no significant association between the groups in terms of TG, TC, HDL-C, LDL-C, VLDL and apoA.
Low level of serum HDL-C in gastric cancer correlates with cancer progression but not patient's survival.
血脂水平在胃癌中的临床意义仍不明确。本研究旨在探讨血清血脂水平与胃癌患者临床参数及预后之间的相关性。
回顾性评估2001年至2009年间接受手术的358例胃癌患者术前血浆血脂水平，并分析这些因素与患者临床参数及生存率之间的相关性。
血清高密度脂蛋白胆固醇水平（HDL-C<54.2mg/dL）与癌症进展之间存在显著关联，Logistic回归分析显示，血清HDL-C水平较低是胃癌患者癌症浸润更深、淋巴结转移及晚期的独立危险因素。然而，未报告其他血脂标志物[甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白（VLDL）和载脂蛋白A（apoA）]与淋巴结受累及疾病分期之间存在显著关联。在关于患者生存的单因素分析和多因素分析中，各亚组在TG、TC、HDL-C、LDL-C、VLDL和apoA方面无显著关联。
胃癌患者血清HDL-C水平低与癌症进展相关，但与患者生存率无关。
