Lee Yongchan, Overholtzer Michael
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cell Res. 2015 Jun;25(6):647-8. doi: 10.1038/cr.2015.57. Epub 2015 May 8.
Cell-in-cell structures resulting from live cell engulfment were identified more than 100 years ago, but their physiological significance has remained largely obscure. Now Ni et al. identify a new role for cell-in-cell structure formation, called "in-cell infection" that spreads Epstein-Barr virus from infected B cells to epithelial cells, an activity that may predispose to cancer.
100多年前就已发现由活细胞吞噬产生的细胞内细胞结构,但其生理意义在很大程度上仍不清楚。现在,倪等人确定了细胞内细胞结构形成的一种新作用,即“细胞内感染”,它将爱泼斯坦-巴尔病毒从受感染的B细胞传播到上皮细胞,这种活动可能会引发癌症。