Kostić N, Bozanić M, Cvetković R
Srp Arh Celok Lek. 1989 May-Jun;117(5-6):325-34.
There are many epidemiological papers on the relation of lipids especially of cholesterol, and the incidence of colorectal adenoma and cancer. In the studies of pathogenesis of the cancer of the large intestine attention is paid to the role of certain lipoproteins of bile acids and certain gastrointestinal hormones. We examined 30 patients: 10 were healthy subjects (the control group), 9 with colorectal adenoma, 2 with villous adenoma and 9 with adenocarcinoma of the colon and the rectum. The study concerned: total lipids, total cholesterol, total triglycerides, LDL cholesterol, HDL cholesterol, phospholipids, gastrinaemia and insulinaemia. Statistical analysis of the obtained results showed that hypocholesterolemia followed the incidence of adenocarcinoma. This is in accordance with the most frequently quoted literature. The incidence of hypergastrinaemia, however, was found primarily in the patients with villous adenoma, which indicates possible secretory function of the studied tumours.
有许多关于脂质尤其是胆固醇与结直肠腺瘤及癌症发病率关系的流行病学论文。在大肠癌症发病机制的研究中，人们关注某些胆汁酸脂蛋白和某些胃肠激素的作用。我们检查了30名患者：10名是健康受试者（对照组），9名患有结直肠腺瘤，2名患有绒毛状腺瘤，9名患有结肠和直肠癌。该研究涉及：总脂质、总胆固醇、总甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、磷脂、胃泌素血症和胰岛素血症。对所得结果的统计分析表明，低胆固醇血症与腺癌的发病率相关。这与最常引用的文献一致。然而，高胃泌素血症的发病率主要在绒毛状腺瘤患者中发现，这表明所研究的肿瘤可能具有分泌功能。
