Vasil'chenko E M, Beĭko V A, Karpov R S, Kanskaia N V
Ter Arkh. 1989;61(9):56-9.
In a study of the effect of lipoproteins of atherogenic classes on proliferative activity of peripheral lymphocytes in patients (n = 44) with ischemic heart disease (IHD) and healthy subjects (n = 16), VLDL isolated from hyperlipidemia blood were shown to have a more suppressive effect on proliferation of PHA-induced lymphocytes than those from healthy subjects. Effect analysis of VLDL isolated from patients with different hyperlipidemia types revealed that VLDL obtained from high triglyceride plasma depressed proliferation 85-75%, while VLDL withdrawn from high cholesterol plasma 45-55% (p less than 0.05). With addition of modified (oxidized) VLDL to PHA-activated lymphocytes oxidized VLDL were demonstrated to have a greater inhibitory effect as compared with intact VLDL. The observed peculiarities of the VLDL effect in hyperlipidemia may underlie the reduced functional activity of lymphocytes, discovered in IHD patients (n = 81).
在一项针对缺血性心脏病（IHD）患者（n = 44）和健康受试者（n = 16）的研究中，研究了致动脉粥样化类脂蛋白对外周淋巴细胞增殖活性的影响。结果显示，从高脂血症血液中分离出的极低密度脂蛋白（VLDL）对PHA诱导的淋巴细胞增殖的抑制作用比从健康受试者血液中分离出的VLDL更强。对从不同类型高脂血症患者中分离出的VLDL的效应分析表明，从高甘油三酯血浆中获得的VLDL可使增殖降低85 - 75%，而从高胆固醇血浆中提取的VLDL可使增殖降低45 - 55%（p小于0.05）。将修饰（氧化）的VLDL添加到PHA激活的淋巴细胞中后，发现氧化型VLDL与完整的VLDL相比具有更大的抑制作用。高脂血症中观察到的VLDL效应的这些特性可能是IHD患者（n = 81）中发现的淋巴细胞功能活性降低的原因。
