Song Taejong, Lee Yoo-Young, Choi Chel Hun, Kim Tae-Joong, Lee Jeong-Won, Bae Duk-Soo, Kim Byoung-Gie
Department of Obstetrics & Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Obstetrics & Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Eur J Obstet Gynecol Reprod Biol. 2015 Jul;190:26-30. doi: 10.1016/j.ejogrb.2015.04.005. Epub 2015 Apr 16.
The aim of this study was to assess the relative incidences of cervical adenocarcinoma in situ (AIS) and squamous cell carcinoma in situ (sCIS) and to determine the effect of coexisting squamous cell lesions on prognosis in patients with cervical AIS.
We performed a retrospective review of patients diagnosed with AIS or sCIS who underwent cervical conization at a University hospital between 2000 and 2011.
A total of 1184 patients with cervical carcinoma in situ were included. The ratio of sCIS to AIS was 16:1. Among 71 patients with AIS, AIS with coexisting squamous cell lesions and AIS alone were detected in 41 patients (58%) and 30 patients (42%), respectively. During the median follow-up of 57.1 months, 5 episodes of AIS recurrences and one episode of invasive recurrence occurred. The recurrence rate was significantly higher in patients with AIS alone than in patients with AIS and coexisting squamous cell lesions (17% versus 2%; P=0.043).
These results suggest that patients with cervical AIS and coexisting squamous cell lesions have a more favorable prognosis than patients with AIS alone.
本研究旨在评估宫颈原位腺癌（AIS）和原位鳞状细胞癌（sCIS）的相对发病率，并确定共存的鳞状细胞病变对宫颈AIS患者预后的影响。
我们对2000年至2011年间在一所大学医院接受宫颈锥切术的诊断为AIS或sCIS的患者进行了回顾性研究。
共纳入1184例宫颈原位癌患者。sCIS与AIS的比例为16:1。在71例AIS患者中，分别在41例（58%）和30例（42%）患者中检测到伴有共存鳞状细胞病变的AIS和单纯AIS。在中位随访57.1个月期间，发生了5次AIS复发和1次浸润性复发。单纯AIS患者的复发率显著高于伴有共存鳞状细胞病变的AIS患者（17%对2%；P=0.043）。
这些结果表明，伴有共存鳞状细胞病变的宫颈AIS患者比单纯AIS患者预后更好。
