Guzman Rodrigo, Fernandez-García Elisa, Gutierrez-Gonzalez Carlos F, Fernandez Adolfo, Lopez-Lacomba Jose Luis, Lopez-Esteban Sonia
Instituto de Estudios Biofuncionales, Universidad Complutense de Madrid, Madrid, Spain.
Nanomaterials & Nanotechnology Research Center (CINN), [Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Oviedo (UO), Principado de Asturias (PA)], Asturias, Spain
J Biomater Appl. 2016 Jan;30(6):759-69. doi: 10.1177/0885328215584858. Epub 2015 May 7.
Alumina-titanium materials (cermets) of enhanced mechanical properties have been lately developed. In this work, physical properties such as electrical conductivity and the crystalline phases in the bulk material are evaluated. As these new cermets manufactured by spark plasma sintering may have potential application for hard tissue replacements, their biocompatibility needs to be evaluated. Thus, this research aims to study the cytocompatibility of a novel alumina-titanium (25 vol. % Ti) cermet compared to its pure counterpart, the spark plasma sintered alumina. The influence of the particular surface properties (chemical composition, roughness and wettability) on the pre-osteoblastic cell response is also analyzed. The material electrical resistance revealed that this cermet may be machined to any shape by electroerosion. The investigated specimens had a slightly undulated topography, with a roughness pattern that had similar morphology in all orientations (isotropic roughness) and a sub-micrometric average roughness. Differences in skewness that implied valley-like structures in the cermet and predominance of peaks in alumina were found. The cermet presented a higher surface hydrophilicity than alumina. Any cytotoxicity risk associated with the new materials or with the innovative manufacturing methodology was rejected. Proliferation and early-differentiation stages of osteoblasts were statistically improved on the composite. Thus, our results suggest that this new multifunctional cermet could improve current alumina-based biomedical devices for applications such as hip joint replacements.
具有增强机械性能的氧化铝-钛材料（金属陶瓷）最近已被开发出来。在这项工作中，对诸如电导率和块状材料中的晶相之类的物理性质进行了评估。由于这些通过放电等离子体烧结制造的新型金属陶瓷可能在硬组织替代方面有潜在应用，因此需要评估它们的生物相容性。因此，本研究旨在研究一种新型氧化铝-钛（25体积%钛）金属陶瓷与其纯对应物——放电等离子体烧结氧化铝相比的细胞相容性。还分析了特定表面性质（化学成分、粗糙度和润湿性）对前成骨细胞反应的影响。材料电阻表明，这种金属陶瓷可以通过电蚀加工成任何形状。所研究的试样具有略微起伏的形貌，粗糙度图案在所有方向上具有相似的形态（各向同性粗糙度）且平均粗糙度为亚微米级。发现了偏度差异，这意味着金属陶瓷中存在谷状结构而氧化铝中以峰为主。金属陶瓷比氧化铝具有更高的表面亲水性。排除了与新材料或创新制造方法相关的任何细胞毒性风险。在复合材料上，成骨细胞的增殖和早期分化阶段在统计学上得到了改善。因此，我们的结果表明，这种新型多功能金属陶瓷可以改进当前基于氧化铝的生物医学装置，用于诸如髋关节置换等应用。
