Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-749 (Korea).
The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 305-701 (Korea).
Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7587-91. doi: 10.1002/anie.201502177. Epub 2015 May 8.
Advanced technologies that can mimic hierarchical architectures found in nature can provide pivotal clues for elucidating numerous biological mechanisms. Herein, a novel technology, spontaneous organization of numerous-layer generation by electrospray (SpONGE), was developed to create self-assembled and multilayered fibrous structures. The simple inclusion of salts in a polymer solution prior to electrospraying was key to mediating the structural versatilities of the fibrous structures. The SpONGE matrix demonstrated great potential as a crucial building block capable of inducing sequential, localized drug delivery or orchestrating cellular distribution in vivo, thereby expanding its scope of use to cover a variety of biomedical applications.
先进的技术可以模拟自然界中发现的分层结构，为阐明许多生物学机制提供关键线索。在此，开发了一种新的技术，即电喷雾自发多层生成（SpONGE），用于创建自组装和多层纤维结构。在电喷雾之前将盐简单地包含在聚合物溶液中是调节纤维结构结构多功能性的关键。SpONGE 基质具有作为关键构建块的巨大潜力，能够在体内诱导顺序、局部药物递送或协调细胞分布，从而将其应用范围扩展到各种生物医学应用。
