Zhang Yiming, Xue Yueguang, Ren Yan, Li Xin, Liu Ying
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450003, China.
GBA National Institute for Nanotechnology Innovation, Guangzhou 510700, China.
Polymers (Basel). 2023 Mar 21;15(6):1566. doi: 10.3390/polym15061566.
With the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain limitations. Biodegradable polymer electrospinning technology with good biocompatibility and degradability can effectively repair tendons, and its mechanical properties can be achieved by adjusting the fiber diameter and fiber spacing. Here, this review first briefly introduces the structure and function of the tendon and the repair process after injury. Then, different kinds of biodegradable natural polymers for tendon repair are summarized. Then, the advantages and disadvantages of three-dimensional (3D) electrospun products in tendon repair and regeneration are summarized, as well as the optimization of electrospun fiber scaffolds with different bioactive materials and the latest application in tendon regeneration engineering. Bioactive molecules can optimize the structure of these products and improve their repair performance. Importantly, we discuss the application of the 3D electrospinning scaffold's superior structure in different stages of tendon repair. Meanwhile, the combination of other advanced technologies has greater potential in tendon repair. Finally, the relevant patents of biodegradable electrospun scaffolds for repairing damaged tendons, as well as their clinical applications, problems in current development, and future directions are summarized. In general, the use of biodegradable electrospun fibers for tendon repair is a promising and exciting research field, but further research is needed to fully understand its potential and optimize its application in tissue engineering.
随着老化后的退变以及高强度运动造成的破坏，肌腱损伤的发生率也在不断增加，这会导致严重的疼痛和功能障碍。由于肌腱组织的结构特殊性，传统的肌腱损伤修复治疗存在一定局限性。具有良好生物相容性和可降解性的可生物降解聚合物静电纺丝技术能够有效修复肌腱，其力学性能可通过调节纤维直径和纤维间距来实现。在此，本综述首先简要介绍肌腱的结构与功能以及损伤后的修复过程。接着，总结用于肌腱修复的不同种类可生物降解天然聚合物。然后，总结三维（3D）静电纺丝产品在肌腱修复与再生中的优缺点，以及不同生物活性材料对静电纺丝纤维支架的优化及其在肌腱再生工程中的最新应用。生物活性分子能够优化这些产品的结构并提高其修复性能。重要的是，我们讨论3D静电纺丝支架的优越结构在肌腱修复不同阶段的应用。同时，其他先进技术的结合在肌腱修复方面具有更大潜力。最后，总结用于修复受损肌腱的可生物降解静电纺丝支架的相关专利，以及它们的临床应用、当前发展中存在的问题和未来方向。总体而言，使用可生物降解静电纺丝纤维进行肌腱修复是一个有前景且令人兴奋的研究领域，但需要进一步研究以充分了解其潜力并优化其在组织工程中的应用。
